Substance dependence
MONDO:0004938The psychological or physiological need to take a substance in order to experience its effects or to avoid the effects of its absence.
Also known as: dependence
1374 clinical trials for this condition and its sub-types, 15 tagged with Substance dependence itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Substance dependence
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Drug dependence 14 trials · 1,285 incl. sub-types
10 sub-types
- Opiate dependence 545 trials Sub-types →
- Nicotine dependence 412 trials
- Cannabis dependence 218 trials
- Methamphetamine dependence 63 trials
- Cocaine dependence 52 trials
- Alcohol dependence 44 trials
- Hallucinogen dependence 1 trial
- Alcohol and nicotine codependence 0 trials
- Barbiturate dependence 0 trials
- Phencyclidine abuse 0 trials
Most studied deeper sub-types
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Telehealth counseling may break down barriers to opioid treatment for veterans
Disease control OngoingThis study tests whether a telehealth-delivered counseling program, called VetReach, can help veterans with opioid use disorder engage in treatment and improve their outcomes. The program combines motivational interviewing and cognitive behavioral therapy, delivered remotely. Res…
Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Jul 26, 2026 00:00 UTC
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University health survey aims to uncover hidden struggles of students and staff
Knowledge-focused OngoingThis study is a health check for students at Constructor University Bremen and employees at HAW-Hamburg. Researchers will use surveys and interviews to measure loneliness, anxiety, stress, and health habits. The goal is to understand what affects wellbeing and find ways to suppor…
Sponsor: Jacobs University Bremen gGmbH • Aim: Knowledge-focused
Last updated Sep 16, 2026 00:00 UTC
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Remote therapy for alcohol problems put to the test
Knowledge-focused OngoingThis study tests whether telehealth programs can help people manage their alcohol use and improve well-being. About 300 adults with alcohol use disorder will join remotely via video or phone. They will be split into two groups: one gets a telehealth program, the other gets usual …
Sponsor: University of Michigan • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Can video chats help treat addiction? new study aims to find out
Knowledge-focused OngoingThis study looks at whether counseling sessions done over video call (telehealth) are practical and well-liked by people with substance use disorder who are not currently getting treatment. About 50 participants will try the program and share their feedback through surveys. The g…
Sponsor: University of Michigan • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC