Sinusitis

This study will compare three FDA-approved biologic drugs (dupilumab, omalizumab, and mepolizumab) in 504 adults with chronic sinusitis and nasal polyps. The goal is to see which drug works best for different patients and whether simple tests can predict who will improve the most…

This study is testing a new seawater spray with essential oils to see if it safely relieves nasal congestion from colds, sinus infections, or allergies. About 101 people aged 12 and older will use the spray for 8 days. The main goal is to check if nasal stuffiness improves by at …

This study is testing a seawater spray mixed with essential oils to see how well it relieves nasal congestion from colds, sinus infections, or allergies. About 114 people aged 12 and older will use the spray for 7 days. The main goal is to see if nasal blockage improves after 3 d…

This study tests whether adding lymphatic pump osteopathic manipulative therapy (OMT) to standard care helps older adults recover faster from respiratory illnesses like bronchitis, sinusitis, or pneumonia. Participants aged 65 to 100 with a new respiratory diagnosis will receive …

This study is testing four medical devices (PIR, NS, NHE, NHG) in 150 adults with acute viral rhinitis, rhinosinusitis, or rhinopharyngitis (common cold). The goal is to see if they are safe and help reduce symptoms like sneezing, runny nose, and sore throat. Participants use the…

This Phase 3 trial tests whether the drug Raphamin can quickly improve symptoms of acute rhinosinusitis (sinus infection) in adults. About 552 participants will receive either Raphamin or a placebo for a few days. The main goal is to see if more people feel much better by day 4 o…

This study looks at whether antibiotics, nasal steroids, or nasal irrigation work best for treating sinus infections. About 3,720 adults with acute sinusitis will be randomly assigned to one of these treatments or a placebo. The goal is to see which approach provides the most sym…

This study compares two ways to treat chronic sinusitis with nasal polyps: a new in-clinic procedure done under local anesthesia versus standard sinus surgery in an operating room. Researchers will enroll 140 adults to see if the in-clinic approach controls symptoms just as well,…

This study is building a large online registry of US adults who experience sinus, ear, dizziness, and headache symptoms, with or without a migraine diagnosis. Participants answer questions about their symptoms, how these affect daily life, and which treatments they have tried. Th…

This study is observing how doctors manage complicated infections of the ears, nose, throat, and neck in both children and adults. Researchers will track standard treatments like surgery or medication to understand current practices. No new treatments are being tested; the goal i…

This study is observing 120 patients with sinonasal or skull-base tumours at a specialist ear, nose, and throat centre. Researchers are tracking how these conditions are managed, what the outcomes are, and how patients' quality of life changes. The goal is to better understand cu…

This study looks at whether a partial problem with a salt channel (CFTR) in the nose contributes to chronic sinusitis. Researchers will measure how well the nose clears mucus in 20 people with sinusitis and healthy volunteers. The goal is to understand the disease better, not to …

This study tests whether a two-part approach—improving communication about viral infections and having pharmacists double-check prescription lengths—can reduce how many days antibiotics are prescribed for respiratory infections like bronchitis, sinusitis, and sore throat. About 4…