Secondary progressive multiple sclerosis

This phase 2 trial tests whether indapamide, a common diuretic, can slow the worsening of walking ability in people with progressive multiple sclerosis (MS). Participants take one tablet daily for 12 months, with walking speed measured regularly. The study aims to see if the drug…

This trial tests an experimental therapy called SYS6020 for people with relapsing or progressive multiple sclerosis that hasn't responded well to standard treatments. SYS6020 uses a patient's own immune cells, engineered to target and potentially reduce harmful B cells involved i…

This early study tests an experimental drug called STR-P005 in people with autoimmune diseases that have come back or not improved with standard treatments. The drug is given through an IV in multiple doses. The main goal is to check safety and see how the body handles the drug. …

This early study tests a new drug called STR-P005 in 18 people with autoimmune diseases that have not responded to standard treatments. The main goal is to check safety and find the best dose. Participants receive the drug by infusion in different schedules, and researchers will …

This study tests an experimental drug called remibrutinib in 20 people with relapsing or progressive multiple sclerosis (MS). Participants take the drug twice daily for 2 years and undergo powerful 7T MRI scans to measure changes in brain volume, lesions, and tissue health. The g…

This early-stage trial tests a new treatment for multiple sclerosis (MS) that combines a drug called ofatumumab with NK042, a therapy made from immune cells donated by healthy people. The study will include 20 adults with different types of MS and will primarily check for safety …

This study tests whether a single dose of amoxicillin before a simple tooth extraction can prevent infections in people with autoimmune rheumatic diseases who are on immune-suppressing medications. Researchers will compare infection rates between those who get the antibiotic and …

This trial investigates whether annual re-screening for tuberculosis infection using a blood test (IGRA) can prevent active TB in people with autoimmune rheumatic diseases who are taking biologic or immunosuppressive medications. Participants who initially test negative for TB ar…

This study tests whether a powered hip-flexion device called Hypershell X can immediately improve walking in people with multiple sclerosis who have hip weakness. Ten participants will walk short distances with the device set to different levels of assistance. Researchers will me…

This study tests a six-month personalized telenursing program for 110 adults with multiple sclerosis. Participants receive monthly educational videos and nurse-led video calls to help them better understand their health and navigate the healthcare system. The goal is to improve h…

This study tests whether breathing low-oxygen air for short periods right before walking training helps people with multiple sclerosis walk better and farther. Thirty-five participants will receive either the low-oxygen breathing or a sham (placebo) version, followed by treadmill…

This early-stage trial tests whether a combination of two drugs, dasatinib and quercetin, can safely remove aged, damaged cells that may contribute to inflammation and nerve damage in people with secondary progressive multiple sclerosis (MS). The study enrolls 30 adults aged 50-8…

This study looks at whether the time of day you eat can affect brain health in people with multiple sclerosis. Twenty-two adults with MS will follow a daily eating schedule for a set period. Researchers will measure markers of nerve health and inflammation in the blood. A small g…

This study will test a new way to offer vaccines to vulnerable patients—those with chronic diseases or weakened immune systems—during hospital visits. Researchers will see if offering, prescribing, and giving vaccines in the hospital increases how many people get vaccinated. The …

This study will collect health data and samples from 100 people with multiple sclerosis over several years. Researchers will use artificial intelligence and data science to find patterns that could help predict how the disease will progress. The goal is to eventually personalize …

This study looks at 70 children aged 1 month to 18 years who have neurological disorders like epilepsy, migraine, or stroke. Researchers will use echocardiograms and ECGs to check for hidden heart problems. The goal is to understand if heart issues are common in these children an…