Sciatic neuropathy
MONDO:0006960Disease or damage involving the SCIATIC NERVE, which divides into the PERONEAL NERVE and TIBIAL NERVE (see also PERONEAL NEUROPATHIES and TIBIAL NEUROPATHY). Clinical manifestations may include SCIATICA or pain localized to the hip, PARESIS or PARALYSIS of posterior thigh muscles and muscles innervated by the peroneal and tibial nerves, and sensory loss involving the lateral and posterior thigh, posterior and lateral leg, and sole of the foot. The sciatic nerve may be affected by trauma; ISCHEMIA; COLLAGEN DISEASES; and other conditions. (From Adams et al., Principles of Neurology, 6th ed, p1363)
65 clinical trials for this condition and its sub-types.
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Broader categories
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New hope for back pain sufferers: no surgery needed?
Symptom relief OngoingThis study looks at whether a non-surgical treatment called spinal decompression can help people with chronic low back pain. About 42 adults with back pain from disc problems or sciatica will receive the treatment over 12 weeks. Researchers will use MRI scans and movement tests t…
Phase: NA • Sponsor: University of South Florida • Aim: Symptom relief
Last updated Jun 27, 2026 12:34 UTC
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Can remote rehab beat home workouts for piriformis pain?
Symptom relief ENROLLING_BY_INVITATIONThis study compares two exercise programs—asynchronous telerehabilitation (remote guidance) and a standard home exercise plan—for people with piriformis syndrome, a condition causing buttock and leg pain. About 46 adults aged 18-45 with confirmed diagnosis will participate. The g…
Phase: NA • Sponsor: Hacettepe University • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC
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Massage showdown: which therapy eases piriformis pain best?
Symptom relief ENROLLING_BY_INVITATIONThis study compares two types of hands-on therapy—Stecco Fascial Manipulation and Rolfing Structural Integration—for people with piriformis syndrome, a condition that causes buttock and leg pain. Forty-two adults aged 25 to 45 with at least four weeks of pain will receive four we…
Phase: NA • Sponsor: Danyal Ahmad • Aim: Symptom relief
Last updated Jun 27, 2026 08:08 UTC
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Can herbs and spinal manipulation ease chronic back pain? new study investigates
Symptom relief OngoingThis study looks at whether a combination of herbal medicine and Chuna manual therapy (a Korean spinal manipulation technique) can safely reduce pain and improve walking ability in people with low back pain or sciatica caused by lumbar spinal stenosis or spondylolisthesis. Resear…
Sponsor: Jaseng Medical Foundation • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Simple stretches may ease piriformis pain: new study
Symptom relief OngoingThis study looks at whether adding dynamic stretching to foam rolling helps people with piriformis syndrome more than foam rolling alone. Forty adults aged 35–50 with buttock pain will do either foam rolling or foam rolling plus dynamic stretches for several weeks. Researchers wi…
Phase: NA • Sponsor: University of Lahore • Aim: Symptom relief
Last updated Jun 27, 2026 08:03 UTC
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Flat feet may be tied to a common cause of hip pain, study suggests
Knowledge-focused OngoingThis study looks at whether people with flat feet (pes planus) are more likely to have piriformis syndrome, a condition that causes pain in the hip and lower back. Researchers will compare foot posture and pain in adults aged 18-65 who have piriformis syndrome with those who do n…
Sponsor: Kahramanmaras Sutcu Imam University • Aim: Knowledge-focused
Last updated Jul 01, 2026 00:00 UTC
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Leg stretch may alter nerve pain sensitivity, tiny study hints
Knowledge-focused ENROLLING_BY_INVITATIONThis study tests whether a specific leg stretching technique, called sciatic nerve mobilization, can change how sensitive the nerves in your lower leg are to pressure pain. 34 healthy university students will either receive the stretch or no treatment. Researchers will measure pa…
Phase: NA • Sponsor: Fenerbahce University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:25 UTC