Retroperitoneal sarcoma

This early-phase trial is testing whether the drug abemaciclib, when given with radiation therapy before surgery, can safely shrink high-risk retroperitoneal liposarcomas. About 18 adults with this rare cancer will receive the combination to find the best dose and check for side …

This study is for people with a rare, high-risk cancer called retroperitoneal sarcoma. It compares two approaches: getting chemotherapy before surgery versus surgery alone. The goal is to see if the chemo-first approach helps prevent the cancer from coming back. About 250 partici…

This study tests two types of radiation therapy—proton beam or advanced photon (IMRT)—given before surgery for retroperitoneal sarcoma, a rare tumor deep in the abdomen. The goal is to find the highest safe dose that can be delivered to high-risk areas of the tumor while protecti…

This study follows 100 adults whose retroperitoneal liposarcoma has returned after initial surgery. Researchers will compare outcomes of surgery alone versus radiation and/or chemotherapy before surgery. The goal is to improve treatment decisions and validate a prediction tool fo…

This early-phase trial tests a new type of proton radiation called P-SFRT, which delivers high doses to tumors while sparing nearby organs. It is for people with newly diagnosed retroperitoneal soft tissue sarcoma that has not been treated yet. The study aims to find the best dos…

This study tests a treatment called electrochemotherapy for people with tumors in organs like the liver or pancreas that cannot be removed by surgery. The treatment uses short electrical pulses to help chemotherapy drugs enter cancer cells more effectively. The goal is to shrink …

This study tests a new, faster radiation treatment using protons or carbon ions before surgery for a rare type of cancer called retroperitoneal soft tissue sarcoma. The goal is to see if this approach is safe and practical. About 64 adults whose tumors can be surgically removed w…

This trial is testing a new type of radiation therapy given before surgery for retroperitoneal sarcoma, a rare cancer in the abdomen. The radiation is delivered in just five high-dose sessions, targeting the tumor and any nearby nodules. The goal is to see if this approach reduce…

This early-phase trial tests a shorter, more intense radiation schedule for people with retroperitoneal sarcoma, a rare cancer in the abdomen. The main goal is to check safety and side effects like nausea and diarrhea within 30 days. Only 6 participants will be enrolled to see if…

This study follows 120 adults with retroperitoneal sarcoma who need surgery that also removes part of the colon or rectum. Researchers will compare different surgical techniques and track complications and quality of life using surveys. The goal is to provide better guidance for …

This study is collecting tissue samples and medical data from 800 high-risk sarcoma patients to develop personalized treatment approaches. Researchers will analyze genetic and protein profiles to better predict which patients benefit from chemotherapy before surgery. The goal is …