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REM sleep behavior disorder
MONDO:0005937A disorder characterized by episodes of vigorous and often violent motor activity during rem sleep (sleep, rem). The affected individual may inflict self injury or harm others, and is difficult to awaken from this condition. Episodes are usually followed by a vivid recollection of a dream that is consistent with the aggressive behavior. This condition primarily affects adult males. (From Adams et al., Principles of Neurology, 6th ed, p393)
55 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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Can a common arthritis drug stop Parkinson's before it starts?
Prevention Not yet recruitingThis study tests whether adalimumab, an anti-inflammatory drug, can prevent brain changes linked to Parkinson's disease in 108 people with REM sleep behavior disorder (RBD). RBD often precedes Parkinson's. Participants will receive adalimumab or a placebo every two weeks for two …
Phase: PHASE2 • Sponsor: Yale University • Aim: Prevention
Last updated Jul 02, 2026 00:00 UTC
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Lifestyle overhaul may slow Parkinson's onset
Prevention Not yet recruitingThis study tests whether a 6-month program combining exercise, Mediterranean diet, sleep counseling, and cognitive training can help people with early Parkinson's or a sleep disorder (RBD) stick to healthy habits. Researchers will track how well 99 participants follow the program…
Phase: NA • Sponsor: University Hospital Schleswig-Holstein • Aim: Prevention
Last updated Jun 27, 2026 08:06 UTC
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Can a narcolepsy drug fix ICU sleep problems?
Symptom relief Not yet recruitingThis study tests whether a drug called gamma-hydroxybutyrate (GHB) can help intensive care patients get better deep sleep. Sleep problems are very common in the ICU and can lead to serious issues like confusion and longer recovery. The trial will give GHB or a placebo to 24 adult…
Phase: PHASE2 • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC
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Can a bedtime pill fix sleep troubles in kids with anorexia?
Symptom relief Not yet recruitingThis study tests a slow-release melatonin (PedPRM) in 120 children aged 6 to 18 who have anorexia nervosa and trouble sleeping. Participants take either melatonin or a placebo for 13 weeks. The goal is to see if it safely improves total sleep time and related symptoms like anxiet…
Phase: PHASE3 • Sponsor: Assistance Publique Hopitaux De Marseille • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
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Smartwatch vibration therapy tested for warfighter nightmares and insomnia
Symptom relief Not yet recruitingThis study tests whether a special smartwatch can improve sleep in warfighters who have trouble sleeping due to PTSD, traumatic brain injury, or stress. The watch detects signs of stress during sleep, like a fast heart rate, and gives gentle vibrations to calm the body without wa…
Phase: NA • Sponsor: Uniformed Services University of the Health Sciences • Aim: Symptom relief
Last updated Jun 27, 2026 12:25 UTC
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Sleep therapy could be key to preventing suicide in young adults
Symptom relief Not yet recruitingThis study looks at whether adding sleep-focused treatments to standard psychiatric care can reduce suicide risk in young adults. About 90 college students with suicidal thoughts and sleep problems will be randomly assigned to one of three sleep interventions. Researchers will tr…
Phase: NA • Sponsor: University of Pittsburgh • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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New study aims to unravel Parkinson's protein mysteries
Knowledge-focused Not yet recruitingThis study looks at how abnormal proteins, like alpha-synuclein and tau, build up and affect brain function in people with Parkinson's disease. Researchers will use brain scans, blood tests, and skin biopsies to track these changes. The goal is to find better ways to diagnose and…
Phase: NA • Sponsor: University of Pavia • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:28 UTC
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Brain scans aim to uncover hidden risk in Parkinson's patients
Knowledge-focused Not yet recruitingThis study will use PET-MRI brain scans to compare the reward system in 44 Parkinson's patients, some of whom have a sleep disorder called RBD. The goal is to understand why some patients develop impulse control problems, like gambling or compulsive behaviors, as a side effect of…
Phase: NA • Sponsor: University Hospital, Clermont-Ferrand • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:01 UTC