Reactive cutaneous fibrous lesion

This pilot study is testing whether radiation therapy can safely treat keloids (raised scars) when surgery isn't an option or has been refused. Fifteen adults with keloids will receive radiation over several sessions. Researchers will track side effects and measure if the keloids…

This study tests a freezing device called Nitrofreeze Skin Tag for removing skin tags. 56 healthy adults will have their skin tags frozen up to three times over 60 days. A blinded doctor will check if the skin tag disappears. The goal is to see if it works better than a similar p…

This study tests whether the drug ritlecitinib can prevent keloids from returning after surgical removal. Keloids are raised, often itchy scars that grow beyond the original wound. The trial will enroll 30 adults who will take a daily pill for 36 weeks. Researchers will measure k…

This study is testing whether a special PET-CT scan using a radioactive tracer called 68Ga-RGD can help doctors diagnose keloids and see how well treatment is working. Keloids are raised scars that grow beyond the original wound, and current diagnosis relies on physical exams. Th…

This study is testing a software tool called Belle.ai that uses artificial intelligence to help doctors diagnose common skin diseases. About 400 patients at dermatology clinics will have three photos taken of their skin condition. The AI will analyze the photos and suggest possib…

This study tests if applying a brief cold spray to keloid or hypertrophic scars right before a steroid injection can reduce pain and make the injection easier. About 30 adults will have each scar split into two halves: one half gets cold therapy plus the injection, the other gets…

This study tests a new drug called 9MW3811 for people with thick, raised scars that haven't improved in 6 months. About 30 adults will receive either the drug or a placebo to see if it makes scars look and feel better. The goal is to reduce scar thickness, color, pain, and itchin…

This study tests whether adding cryotherapy (freezing) to a standard injection treatment (5FU) works better for keloid scars than the injection alone. About 88 adults with painful or itchy keloids will receive either 5FU injections every 3 weeks or freezing followed by the same i…

This study tests a group counseling program called Healing HEARTS to help people with conditions like obesity, skin disease, cancer, HIV, diabetes, or chronic pain deal with internalized stigma. Participants will either join the counseling program or a peer support group. The goa…

This study tests a scar gel against a leading product to see which better prevents raised scars and improves scar appearance, hydration, and color. Eighty adults with recent scars (from C-sections, breast implants, or cuts) will use the gel daily for 90 days. Doctors and particip…

This study collects biological samples—like blood, skin biopsies, and swabs—from people with or at risk for skin diseases, as well as healthy volunteers. Researchers will use these samples to study the causes of skin conditions and explore potential treatments. Up to 700 particip…

This study aims to find the genes that cause or contribute to keloid scarring. Researchers will analyze DNA from 7,000 people who have keloids, as well as their unaffected family members. The goal is to better understand why some people develop these raised scars, which could lea…

This study looks at how skin conditions related to cancer or cancer treatments affect the well-being of cancer patients and survivors. About 1,025 participants will fill out questionnaires about their skin condition. The goal is to better understand these effects and improve trea…