Rapidly progressive glomerulonephritis
MONDO:0017236Inflammation of the glomeruli that is characterized by a rapid loss in renal function with glomerular crescent formation observed on biopsy; it is often seen in patients with concomitant autoimmune disease, like Goodpasture's syndrome or systemic lupus erythematosus.
Also known as: RPGN, crescentic glomerulonephritis
6 clinical trials for this condition and its sub-types.
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Broader categories
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New drug combo aims to save kidneys in rare autoimmune disease
Disease control Not yet recruitingThis Phase 3 trial tests whether adding avacopan to standard treatment helps people with severe ANCA vasculitis and serious kidney damage. About 130 participants will receive either avacopan or a placebo alongside usual care. The goal is to see if more patients recover kidney fun…
Phase: PHASE3 • Sponsor: University Hospital, Toulouse • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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A simple blood test may reveal kidney damage in lupus — no biopsy needed?
Diagnosis Not yet recruitingThis study asks whether levels of uromodulin, a protein in the blood, can indicate the severity of kidney damage in people with lupus nephritis. Researchers will compare uromodulin levels with kidney biopsy results from 90 participants, including those with different classes of l…
Sponsor: Assiut University • Aim: Diagnosis
Last updated Aug 15, 2026 00:00 UTC