Quadriplegia
MONDO:0001590Paralysis of all four limbs.
Also known as: bilateral diplegia, tetraplegia
66 clinical trials for this condition and its sub-types.
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Spinal cord stimulation may help restore movement after paralysis
Disease control CompletedThis pilot study tests whether electrical stimulation of the spinal cord can improve motor function and reduce spasticity in people with spinal cord injury. Participants receive epidural and dorsal root stimulation during 10 rehabilitation sessions. The study measures changes in …
Phase: NA • Sponsor: Peter J. Grahn, Ph.D. • Aim: Disease control
Last updated Jul 18, 2026 00:00 UTC
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Nerve transfer surgery may restore hand function after spinal cord injury
Disease control CompletedThis trial investigates whether nerve transfer surgery can restore hand function in people with cervical spinal cord injury. Participants undergo a personalized nerve transfer procedure to reconnect nerves and improve arm and hand strength. Researchers track changes in motor stre…
Phase: NA • Sponsor: Washington University School of Medicine • Aim: Disease control
Last updated Jul 08, 2026 00:00 UTC
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Mind over muscles: brain chip lets paralyzed man grasp objects
Disease control CompletedThis study tested whether a person with chronic paralysis from a spinal cord injury could control hand movements using only their thoughts. The participant, who already had a brain implant from the BrainGate study, used a computer to decode their intended grasp patterns. Those si…
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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Can electrical leg biking and diet beat metabolic syndrome in spinal cord injury?
Disease control CompletedThis study tested whether a home exercise program using electrical stimulation to move the legs, combined with a personalized diet, could improve body composition and metabolism in adults with spinal cord injury. Twenty-six participants were assigned to either exercise plus diet …
Phase: NA • Sponsor: University of Miami • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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Electric suit aims to ease spasticity and boost balance in kids with cerebral palsy
Symptom relief CompletedThis trial tests whether a wearable suit called EXOPULSE Mollii, which sends gentle electrical pulses to muscles, can help children with cerebral palsy. The study focuses on kids aged 5 to 12 who have spasticity and some walking ability. Researchers will measure changes in balanc…
Phase: NA • Sponsor: Exoneural Network AB • Aim: Symptom relief
Last updated Aug 07, 2026 00:00 UTC
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Robotic arm could help people with paralysis regain independence at home
Symptom relief CompletedThis study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …
Phase: NA • Sponsor: Association APPROCHE • Aim: Symptom relief
Last updated Jul 04, 2026 00:00 UTC
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Robots vs electricity vs therapy: which best restores hand movement after spinal injury?
Symptom relief CompletedThis completed study tested three different rehabilitation approaches—robotic rehabilitation, functional electrical stimulation (FES), and occupational therapy—to see which works best for improving hand and arm function in people with tetraplegia (paralysis of all four limbs) due…
Phase: NA • Sponsor: Ankara City Hospital Bilkent • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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Shocking therapy may help kids with CP move better
Symptom relief CompletedThis study tested whether task-specific electrical stimulation can improve upper limb motor skills in 30 children aged 4 to 7 with spastic quadriplegia cerebral palsy. The therapy uses mild electrical pulses to activate muscles during functional tasks. The goal was to see if this…
Phase: NA • Sponsor: Kafrelsheikh University • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
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Sound waves aim to calm spastic muscles in spinal injury patients
Symptom relief CompletedThis pilot study tested whether a non-invasive treatment called extracorporeal shockwave therapy (ESWT) can safely reduce spasticity—muscle stiffness and spasms—in people with chronic spinal cord injury. Five participants received ESWT or a sham treatment, and researchers measure…
Phase: NA • Sponsor: Kessler Foundation • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Could VR games help paralyzed patients move their arms again?
Symptom relief CompletedThis study tested whether virtual reality (VR) games could help people with tetraplegia (paralysis of all four limbs) improve arm and hand function during hospital rehabilitation. Twelve participants either received standard therapy or added VR games to their routine for 12 weeks…
Phase: NA • Sponsor: Glasgow Caledonian University • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Which exoskeleton do therapists prefer? a Head-to-Head comparison
Knowledge-focused CompletedThis study asks whether physiotherapists and physical education instructors are more satisfied with certain exoskeleton models used for gait training in rehabilitation. A group of 14 experienced professionals will test three different devices and rate their usability. The goal is…
Sponsor: University of Sao Paulo General Hospital • Aim: Knowledge-focused
Last updated Aug 18, 2026 06:00 UTC
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Virtual reality could help quadriplegics control hand devices before surgery
Knowledge-focused CompletedThis study tested whether virtual reality can be used to evaluate and improve control interfaces for a neuroprosthesis that stimulates hand movements in people with complete tetraplegia (quadriplegia). Ten participants with spinal cord injuries tried two different control methods…
Phase: NA • Sponsor: Centre Bouffard Vercelli - USSAP • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC