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Quadriplegia
MONDO:0001590Paralysis of all four limbs.
Also known as: bilateral diplegia, tetraplegia
59 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Mind over muscles: brain chip lets paralyzed man grasp objects
Disease control CompletedThis study tested whether a person with chronic paralysis from a spinal cord injury could control hand movements using only their thoughts. The participant, who already had a brain implant from the BrainGate study, used a computer to decode their intended grasp patterns. Those si…
Phase: NA • Sponsor: VA Office of Research and Development • Aim: Disease control
Last updated Jun 27, 2026 09:06 UTC
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Can electrical leg biking and diet beat metabolic syndrome in spinal cord injury?
Disease control CompletedThis study tested whether a home exercise program using electrical stimulation to move the legs, combined with a personalized diet, could improve body composition and metabolism in adults with spinal cord injury. Twenty-six participants were assigned to either exercise plus diet …
Phase: NA • Sponsor: University of Miami • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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Robotic arm could help people with paralysis regain independence at home
Symptom relief CompletedThis study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …
Phase: NA • Sponsor: Association APPROCHE • Aim: Symptom relief
Last updated Jul 04, 2026 00:00 UTC
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Robots vs electricity vs therapy: which best restores hand movement after spinal injury?
Symptom relief CompletedThis completed study tested three different rehabilitation approaches—robotic rehabilitation, functional electrical stimulation (FES), and occupational therapy—to see which works best for improving hand and arm function in people with tetraplegia (paralysis of all four limbs) due…
Phase: NA • Sponsor: Ankara City Hospital Bilkent • Aim: Symptom relief
Last updated Jun 27, 2026 13:06 UTC
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Shocking therapy may help kids with CP move better
Symptom relief CompletedThis study tested whether task-specific electrical stimulation can improve upper limb motor skills in 30 children aged 4 to 7 with spastic quadriplegia cerebral palsy. The therapy uses mild electrical pulses to activate muscles during functional tasks. The goal was to see if this…
Phase: NA • Sponsor: Kafrelsheikh University • Aim: Symptom relief
Last updated Jun 27, 2026 13:04 UTC
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Sound waves aim to calm spastic muscles in spinal injury patients
Symptom relief CompletedThis pilot study tested whether a non-invasive treatment called extracorporeal shockwave therapy (ESWT) can safely reduce spasticity—muscle stiffness and spasms—in people with chronic spinal cord injury. Five participants received ESWT or a sham treatment, and researchers measure…
Phase: NA • Sponsor: Kessler Foundation • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Could VR games help paralyzed patients move their arms again?
Symptom relief CompletedThis study tested whether virtual reality (VR) games could help people with tetraplegia (paralysis of all four limbs) improve arm and hand function during hospital rehabilitation. Twelve participants either received standard therapy or added VR games to their routine for 12 weeks…
Phase: NA • Sponsor: Glasgow Caledonian University • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Virtual reality could help quadriplegics control hand devices before surgery
Knowledge-focused CompletedThis study tested whether virtual reality can be used to evaluate and improve control interfaces for a neuroprosthesis that stimulates hand movements in people with complete tetraplegia (quadriplegia). Ten participants with spinal cord injuries tried two different control methods…
Phase: NA • Sponsor: Centre Bouffard Vercelli - USSAP • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:07 UTC