Pulmonary hypoplasia
MONDO:0800133A respiratory malformation characterized by the presence of both bronchi (albeit rudimentary) and alveoli in an under-developed lobe. Both the size and the weight of the lung are reduced. The true prevalence is not well known (1.4% of all births according to Knox et al. 13), but in cases of premature rupture of membranes at 15-28 weeks gestation, the reported prevalence of pulmonary hypoplasia ranges from 9 to 28%. Factors that contribute to pulmonary hypoplasia include adequate volume of the thoracic cavity, pulmonary fluid dynamics, and abnormal fetal breathing movements.
11 clinical trials for this condition and its sub-types.
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Experimental fetal fluid therapy aims to save babies born without kidneys
Disease control CompletedThis trial tests whether repeatedly adding sterile fluid into the womb can help fetuses with severe kidney failure grow enough lungs to survive after birth. Pregnant women with early pregnancy kidney failure can choose to receive the infusions or just be monitored. Babies who sur…
Phase: PHASE1 • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Jul 03, 2026 00:00 UTC
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Balloon in the womb: new device aims to save babies with underdeveloped lungs
Disease control CompletedThis study tested a new device (Smart-TO) that places a small balloon in the windpipe of unborn babies with congenital diaphragmatic hernia, a condition where the diaphragm has a hole and the lungs don't grow properly. The balloon is later removed using a special MRI technique. T…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Disease control
Last updated Jun 27, 2026 07:58 UTC
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Could a common heart drug save babies with a rare birth defect?
Disease control CompletedThis study looked at whether a medicine called milrinone can improve oxygen levels in newborns with congenital diaphragmatic hernia (CDH), a birth defect that causes severe breathing problems. The trial included 66 babies who were on breathing machines. The goal was to see if mil…
Phase: PHASE2 • Sponsor: NICHD Neonatal Research Network • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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Could a tiny dose of muscle relaxant make lung scopes safer?
Symptom relief CompletedThis study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…
Phase: NA • Sponsor: Harbin Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC