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Pulmonary hypoplasia
MONDO:0800133A respiratory malformation characterized by the presence of both bronchi (albeit rudimentary) and alveoli in an under-developed lobe. Both the size and the weight of the lung are reduced. The true prevalence is not well known (1.4% of all births according to Knox et al. 13), but in cases of premature rupture of membranes at 15-28 weeks gestation, the reported prevalence of pulmonary hypoplasia ranges from 9 to 28%. Factors that contribute to pulmonary hypoplasia include adequate volume of the thoracic cavity, pulmonary fluid dynamics, and abnormal fetal breathing movements.
7 clinical trials for this condition and its sub-types.
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Can a tiny balloon in the womb save babies born with a hole in their diaphragm?
Disease control Recruiting nowThis trial tests a procedure called FETO (fetoscopic endoluminal tracheal occlusion) for babies diagnosed before birth with a severe form of congenital diaphragmatic hernia (CDH). In CDH, a hole in the diaphragm lets abdominal organs push into the chest, preventing the lungs from…
Sponsor: Holly L Hedrick, MD • Aim: Disease control
Last updated Jul 24, 2026 00:00 UTC
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Balloon in the womb: new hope for babies with severe birth defect?
Disease control Recruiting nowThis study tests a procedure called FETO for unborn babies with a severe form of congenital diaphragmatic hernia (CDH), where the diaphragm has a hole and the lungs don't grow well. Doctors place a tiny balloon in the baby's windpipe to block it, which may help the lungs expand a…
Sponsor: Rodrigo Ruano • Aim: Disease control
Last updated Jun 27, 2026 09:07 UTC
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Fetal balloon trial aims to save babies with rare birth defect
Disease control Recruiting nowThis phase 3 trial tests a procedure called FETO, where a balloon is placed in the windpipe of a fetus to help lungs grow. It is for pregnant women carrying a baby with severe congenital diaphragmatic hernia, a condition where the diaphragm has a hole and organs move into the che…
Phase 3 • Sponsor: Children's Hospital Medical Center, Cincinnati • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC