Primary orthostatic hypotension
MONDO:0015914Primary orthostatic hypotension is a rare type of orthostatic hypotension. It is not a disease per se, but a condition caused by several disorders that affect a specific part of the autonomic nervous system, such as multiple system atrophy, young-onset Parkinson's disease, pure autonomic failure, dopamine beta-hydroxylase deficiency, familial dysautonomia, and pure autonomic failure among others. The autonomic nervous system is the part of the nervous system that regulates certain involuntary body functions such as heart rate, blood pressure, sweating, and bowel and bladder control. Orthostatic hypotension is a form of low blood pressure that happens when standing-up from sitting or lying down. Common symptoms may include dizziness, lightheadedness, generalized weakness, leg buckling, nausea, blurry vision, fatigue, and headaches. Additional symptoms can include chest pain (angina), head and neck pain (often affecting neck and shoulders with a coat hanger distribution), decline in cognitive functioning such as difficulty concentrating, temporary loss of consciousness or “blackout”. Some people with primary orthostatic hypotension may also have high blood pressure when lying down. The treatment depends upon several factors including the specific underlying cause including The treatment depends upon several factors including the specific underlying cause and may include physical counter-maneuvers like lying down, sitting down, squatting clenching buttocks, leg crossing, and support garment and medication.
Also known as: neurogenic orthostatic hypotension
83 clinical trials for this condition and its sub-types, 12 tagged with Primary orthostatic hypotension itself.
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Browse by category →Sub-types of Primary orthostatic hypotension
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Inherited orthostatic hypotension 0 trials · 71 incl. sub-types
3 sub-types
- Postural orthostatic tachycardia syndrome 71 trials
- Orthostatic hypotension 1 0 trials
- Orthostatic hypotension 2 0 trials
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Could rebreathing your own breath stop the dizziness?
Symptom relief Recruiting nowThis study looks at whether a simple device that makes you breathe in a little extra carbon dioxide (CO2) can help raise blood pressure in people with a condition called neurogenic orthostatic hypotension (nOH). People with nOH get dizzy or even faint when they stand up because t…
Sponsor: University of Calgary • Aim: Symptom relief
Last updated Jun 27, 2026 12:30 UTC
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Could a breath of CO2 stop fainting spells?
Symptom relief Recruiting nowThis study looks at whether breathing air with a little extra carbon dioxide can help people with neurogenic orthostatic hypotension (NOH) — a condition where blood pressure drops sharply upon standing, causing dizziness and fainting. Researchers will test this in 80 adults (pati…
Sponsor: University of Calgary • Aim: Symptom relief
Last updated Jun 27, 2026 12:29 UTC
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Could a sleep apnea machine fix blood pressure swings in nerve disease?
Symptom relief Recruiting nowThis study looks at whether using a CPAP machine (a device that gently blows air through a mask) can safely lower high blood pressure when lying down at night and help reduce dizziness upon standing in people with autonomic failure. About 59 adults aged 40-80 with conditions like…
Sponsor: Vanderbilt University Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 12:04 UTC
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Can a Thigh-Worn sensor outsmart dizziness questionnaires?
Knowledge-focused Recruiting nowThis study explores whether a small accelerometer worn on the thigh can objectively measure how well treatments work for neurogenic orthostatic hypotension—a condition causing dizziness and fainting upon standing. Participants wear the device for one week on placebo and one week …
Sponsor: Vanderbilt University Medical Center • Aim: Knowledge-focused
Last updated Jul 04, 2026 00:00 UTC
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Scientists track rare brain diseases to uncover early warning signs
Knowledge-focused Recruiting nowThis study follows 800 adults with synucleinopathies—diseases like Parkinson's, Lewy body dementia, and multiple system atrophy—to learn how they develop and change over time. Researchers will track symptoms, biological markers, and early signs like dizziness on standing or dream…
Sponsor: NYU Langone Health • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC