Primary hyperthyroidism
MONDO:1060200A form of hyperthyroidism caused by overproduction of thyroid hormones (T3 and T4) due to pathology within the thyroid gland itself. Primary hyperthyroidism is characterized by low TSH levels and elevated T3/T4 levels.
55 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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New drug aims to tame Graves' disease Long-Term
Disease control ENROLLING_BY_INVITATIONThis study tests a drug called IMVT-1402 in adults with Graves' disease, a condition where the immune system attacks the thyroid. The goal is to see if the drug can help patients stay healthy without needing other treatments. About 372 people who completed earlier studies will ta…
Phase: PHASE2 • Sponsor: Immunovant Sciences GmbH • Aim: Disease control
Last updated Jul 29, 2026 00:00 UTC
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New injection every 8 weeks shows promise for thyroid eye disease
Disease control OngoingThis study tests a drug called TOUR006 in 79 people with active thyroid eye disease, a condition that causes eye bulging and inflammation. Participants receive either a low dose, high dose, or placebo injection every 8 weeks. The main goal is to see if the drug can reduce eye bul…
Phase: PHASE2 • Sponsor: Tourmaline Bio, Inc., a Novartis Company • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Dietary intervention aims to tame weight regain in Graves' patients
Disease control OngoingThis study tests whether a personalized low-calorie Mediterranean-style diet, combined with lifestyle coaching, can prevent people newly diagnosed with Graves' disease from regaining too much weight after their thyroid levels normalize. Fifty-four adults will be randomly assigned…
Phase: NA • Sponsor: Istituti Clinici Scientifici Maugeri SpA • Aim: Disease control
Last updated Jun 27, 2026 12:05 UTC
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New registry to see if blocking thyroid blood flow improves symptoms
Disease control ENROLLING_BY_INVITATIONThis registry study follows 100 adults who have had a procedure called thyroid embolization to treat hyperthyroidism, goiter, or thyroid nodules. The procedure uses a catheter to block blood flow to the thyroid, aiming to shrink it and reduce symptoms. Researchers will track chan…
Sponsor: Sarasota Memorial Health Care System • Aim: Disease control
Last updated Jun 26, 2026 14:53 UTC
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ThyMoves study: exercise may ease thyroid symptoms and prevent falls in seniors
Symptom relief ENROLLING_BY_INVITATIONThis study looks at whether a tailored exercise program can improve quality of life, muscle strength, and balance in women aged 65 and older with Hashimoto's thyroiditis or multinodular toxic goiter. Participants will be randomly assigned to either the exercise program or usual c…
Phase: NA • Sponsor: Aalborg University Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 12:09 UTC
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New study sheds light on thyroid disease in kids under 6
Knowledge-focused ENROLLING_BY_INVITATIONThis study examines autoimmune hyperthyroidism in children diagnosed before age 6, focusing on their symptoms, growth, and response to treatment. Researchers will compare these young children with older children who have the same condition. The goal is to identify patterns that c…
Sponsor: IRCCS Ospedale San Raffaele • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:23 UTC
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Vaccine link to thyroid disease under investigation
Knowledge-focused OngoingThis study looks at whether COVID-19 vaccination might trigger Graves' disease, a condition where the immune system attacks the thyroid. Researchers will review medical records of 161 people who developed Graves' disease for the first time between March 2020 and October 2022. The…
Sponsor: Laura ICONARU • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:54 UTC
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Thyroid Surgery's heart impact study pulled before start
Knowledge-focused TerminatedThis study aimed to see if thyroid surgery changes the thickness of the carotid artery, which is a sign of heart disease risk. It planned to measure artery thickness before and after surgery in adults with various thyroid conditions. However, the study was withdrawn before enroll…
Sponsor: Istituto Auxologico Italiano • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC