Primary aldosteronism

This trial asks whether baxdrostat, a daily pill that blocks an enzyme involved in aldosterone production, can reduce the overactive hormone-making spots in the adrenal glands of people with primary aldosteronism. Researchers will use specialized PET-CT scans to measure changes i…

This study tests a procedure that uses a thin needle guided by an endoscope to inject alcohol into a benign adrenal tumor that produces too much aldosterone, a hormone that raises blood pressure. The goal is to destroy the tumor without surgery. The trial enrolls 30 adults with l…

This phase 2 trial tests a new drug called SAL0140 in 50 adults with primary aldosteronism, a condition where the adrenal glands make too much aldosterone, causing high blood pressure. Participants will receive either SAL0140 or a placebo for 12 weeks to see if it safely lowers b…

This study looks at whether giving hydrocortisone for one month after adrenal gland removal can slow kidney function decline in patients with primary aldosteronism and chronic kidney disease. About 90 adults will be randomly assigned to receive either hydrocortisone or standard c…

This study tests an experimental drug called QLS1410 for people with primary aldosteronism, a condition where the adrenal glands make too much aldosterone, causing high blood pressure. The trial will compare the drug to a placebo in 60 adults to see if it safely lowers blood pres…

Researchers compare two ways to find which adrenal gland overproduces aldosterone in people with primary aldosteronism. One method uses a metomidate PET-CT scan with a radioactive tracer; the other uses adrenal vein sampling, an invasive catheter procedure. The trial measures how…

This study tests whether measuring certain hormones in a blood sample can accurately identify which patients with primary aldosteronism (a common cause of high blood pressure) have a curable adrenal tumor. Currently, diagnosis often requires an invasive procedure called adrenal v…

This trial tests whether eplerenone, a drug that blocks the hormone aldosterone, can prevent the onset of high blood pressure in people aged 30–55 who have a mild, early form of primary aldosteronism but normal blood pressure. Participants will receive either eplerenone or a plac…

This pilot study tests whether adding regular sauna sessions to usual care can help lower blood pressure in people with primary aldosteronism, a condition that causes high blood pressure. Ten adults will attend three 30-minute sauna sessions per week for two weeks while wearing a…

This pilot study will test whether a personalized computer model, called a 'digital twin,' can predict which patients with high blood pressure will respond to a procedure called renal denervation. The study will enroll 60 people, including those with resistant hypertension, untre…