Presbycusis

This trial tests an investigational drug called DX243 in people with mild to moderate age-related hearing loss. Participants receive daily injections of DX243 or a placebo for 29 days. The study checks whether the drug is safe and whether it improves hearing, using speech-in-nois…

This study tests whether using hearing aids and related support can help slow memory decline in adults aged 55-75 who have mild to moderate hearing loss and early signs of memory problems. Participants are randomly assigned to receive either a hearing intervention or a health edu…

This study tests whether Apple AirPods can help adults with mild-to-moderate hearing loss understand speech in noisy places. Twenty-four participants will compare AirPods, hearing aids, and wireless microphones in a single lab session. Researchers will measure how well people hea…

This study tests whether a one-month treatment combining the allergy drug clemastine fumarate with engineered sound can improve the ability to hear speech in background noise for people aged 45-65 with age-related central auditory processing disorder (CAPD). About 344 participant…

This study looks at whether combining a non-invasive brain stimulation technique called rTMS with hearing aids can improve cognitive function in older adults with age-related hearing loss. About 189 participants, including those with and without hearing aids, will receive two 14-…

This study tests whether a gentle electrical stimulation on the ear (taVNS) can improve speech understanding in noisy environments for older adults with age-related hearing loss. 36 participants aged 55-80 will receive either active or sham stimulation. The goal is to see if this…

This study tests a new hearing aid, Audiocap, in 100 adults with mild-to-moderate hearing loss who have never used a hearing aid before. The goal is to see if it improves hearing better than a placebo device after one month of use. Participants will undergo standard hearing tests…

This study is testing whether joining a choir for 12 weeks can help older adults (60+) with mild-to-moderate untreated hearing loss understand speech better and improve their mood and social connections. 210 participants will be randomly assigned to either a weekly group singing …

This study investigates whether older adults with age-related hearing loss (presbycusis) can still hear and enjoy the sound of a crunchy biscuit while eating. Researchers will compare a crunchy biscuit with a soft one in 100 seniors aged 65 and older, asking them if they hear the…

This study looks at whether listening to music with a steady beat can improve how older adults with age-related hearing loss process sentences. Researchers will have 55 participants aged 70 or older listen to regular or irregular rhythm music, then judge if sentences are grammati…

This study looks at why some people aged 60 and older have trouble understanding speech in noisy settings, even though their standard hearing tests are normal. Researchers will use hearing tests and brain scans to see if the problem is related to how the brain processes sound tim…

This study uses PET scans to watch brain activity while people with cochlear implants try to understand speech in background noise. Researchers want to pinpoint which brain regions help make sense of sound in challenging listening situations. The study includes 120 cochlear impla…

This study looks at adults aged 30 to 55 who have hearing loss that started after age 16 and carry a mutation in the GJB2 gene. Researchers will track how their hearing changes over time using hearing tests and genetic analysis. The goal is to better understand this form of heari…

This study aims to find out why hearing aids work well in quiet labs but not in noisy real-world settings. About 45 adults with hearing loss who already use hearing aids will listen to different sound scenarios and rate their experience. The goal is to improve hearing aid perform…

This study looks at how older adults with hearing loss understand speech in noisy settings, and how hearing aids can help. Researchers will test 121 people, including young and older adults with normal hearing and older adults with hearing loss. They will measure both behavior (l…