Precocious puberty

This study tests whether a monthly injection of leuprorelin, a drug that blocks puberty hormones, can safely slow or stop early puberty in children diagnosed with central precocious puberty. About 43 children—girls under 9 and boys under 10—will receive the injection every 4 week…

This study tests whether a combination of Chinese herbs (Ziyin-Xiehuo granules) and tiny acupuncture needles placed under the skin can help girls with idiopathic precocious puberty. The 170 participants will receive either the herbs plus acupuncture or a placebo. Researchers will…

This study looks at how things in your environment—like pollution, chemicals, diet, and sleep—might affect your hormones and reproductive health. Researchers will follow 300 people aged 8 and older who have conditions like low or high hormone levels, early or late puberty, or inf…

This natural history study aims to gather information from up to 3,000 people with genetic conditions that cause too much androgen (male-like hormones), such as congenital adrenal hyperplasia (CAH) and familial male-limited precocious puberty (FMPP). Participants undergo various …

This study aims to understand how reproductive disorders, such as delayed or early puberty, are inherited. Researchers will collect blood samples and medical histories from 850 people with these conditions and their family members. No treatment is provided; the goal is to identif…

This study looks at girls aged 6 to 8 who are showing early breast development. Researchers want to understand if chemicals in the environment, called endocrine disruptors, play a role. They will measure these chemicals in hair and blood, and also check body fat and growth. The g…

This study looks at 300 children with central precocious puberty (early puberty) to see how many also have a neurodevelopmental syndrome or condition. Researchers will compare the diagnosis and development of children with early puberty alone versus those with an associated brain…

This observational study will follow 2000 children and adults with imprinting disorders—rare genetic conditions like Silver-Russell and Prader-Willi syndromes. Researchers aim to describe the natural history of these diseases and identify common metabolic profiles, risks for obes…

This study is an observatory that will track up to 3360 children in private healthcare who show signs of early or advanced puberty. Researchers will collect data like height, weight, and pubertal stage to better understand trends and possible causes, such as environmental factors…