Precancerous condition
MONDO:0021074A pathological process with signs indicating it may become cancerous. Representative examples include leukoplakia, dysplastic nevus, actinic keratosis, xeroderma pigmentosum, and intraepithelial neoplasia.
Also known as: precancerous condition, precancerous state, premalignant condition, premalignant state
518 clinical trials for this condition and its sub-types, 51 tagged with Precancerous condition itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
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Sub-types of Precancerous condition
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In situ carcinoma 25 trials · 318 incl. sub-types
21 sub-types
- Breast carcinoma in situ 76 trials · 204 incl. sub-types Sub-types →
- Adenocarcinoma in situ 10 trials · 170 incl. sub-types Sub-types →
- Bladder carcinoma in situ 30 trials
- Intestine carcinoma in situ 0 trials · 16 incl. sub-types Sub-types →
- Uterus carcinoma in situ 0 trials · 16 incl. sub-types Sub-types →
- Esophagus carcinoma in situ 13 trials
- Squamous carcinoma in situ 5 trials · 10 incl. sub-types Sub-types →
- Skin carcinoma in situ 3 trials · 9 incl. sub-types Sub-types →
- Oral cavity carcinoma in situ 5 trials Sub-types →
- Stomach carcinoma in situ 4 trials Sub-types →
- Lung carcinoma in situ 2 trials · 3 incl. sub-types Sub-types →
- Pharynx carcinoma in situ 0 trials · 2 incl. sub-types Sub-types →
- Larynx carcinoma in situ 1 trial Sub-types →
- Carcinoma in situ of ureter 0 trials
- Carcinoma in situ of urethra 0 trials
- Eye carcinoma in situ 0 trials
- Gall bladder carcinoma in situ 0 trials
- Grade III prostatic intraepithelial neoplasia 0 trials
- Kidney carcinoma in situ 0 trials Sub-types →
- Liver carcinoma in situ 0 trials Sub-types →
- Nasal cavity carcinoma in situ 0 trials
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Intraepithelial neoplasia 25 trials · 71 incl. sub-types
3 sub-types
- Squamous cell intraepithelial neoplasia 26 trials · 43 incl. sub-types Sub-types →
- Prostate intraepithelial neoplasia 2 trials Sub-types →
- Small intestinal intraepithelial neoplasia 1 trial
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Pre-malignant neoplasm 2 trials · 43 incl. sub-types
1 sub-type
- Actinic keratosis 41 trials
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Leukoplakia 7 trials · 28 incl. sub-types
5 sub-types
- Oral mucosa leukoplakia 23 trials Sub-types →
- Esophageal leukoplakia 1 trial
- Leukoplakia of penis 0 trials
- Leukoplakia of vagina 0 trials
- Uterine cervix leukoplakia 0 trials
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Premalignant hematological system disease 3 trials · 25 incl. sub-types
2 sub-types
- Clonal hematopoiesis 10 trials · 22 incl. sub-types Sub-types →
- Atypical lymphoproliferative disorder 0 trials
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Gastric intestinal metaplasia 18 trials
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Preneoplastic lesion 8 trials
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Neoplastic polyp 1 trial · 5 incl. sub-types
1 sub-type
- Polyposis 3 trials · 4 incl. sub-types Sub-types →
Most studied deeper sub-types
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Major trial tests gentler radiation combo for HPV throat cancer
Disease control CompletedThis large phase 3 trial studied nearly 1,000 people with HPV-related oropharyngeal cancer to see if replacing chemotherapy with a targeted drug (cetuximab) during radiation could work as well or better. The goal was to find a treatment that controls the disease while possibly re…
Phase 3 • Sponsor: Radiation Therapy Oncology Group • Aim: Disease control
Last updated Jul 22, 2026 00:00 UTC
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New ointment could treat larger patches of Sun-Damaged skin
Disease control CompletedThis study tested an ointment called tirbanibulin (Klisyri®) on adults with actinic keratosis, a common precancerous skin condition caused by sun exposure. The trial included 280 participants and applied the ointment to larger skin areas (up to 100 cm²) on the face or balding sca…
Phase 3 • Sponsor: Almirall, S.A. • Aim: Disease control
Last updated Jul 02, 2026 00:00 UTC
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New drug combo shrinks spleens in bone marrow cancer patients
Disease control CompletedThis study tested a new drug called pelabresib in people with certain blood cancers, including myelofibrosis and leukemia. In the first part, the drug was given alone to find the safest dose. In the second part, it was given with or without another drug (ruxolitinib) to see if it…
Phase 1/2 • Sponsor: Constellation Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 13:02 UTC
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Water-Assisted scope may improve colon polyp removal
Disease control CompletedThis trial tested a new method called underwater ESD for removing large, flat colon polyps. Instead of using gas to inflate the colon, doctors fill it with saline water. The goal was to see if this reduces complications like bleeding or perforation and improves complete removal. …
Sponsor: Istituto Clinico Humanitas • Aim: Disease control
Last updated Jun 27, 2026 12:23 UTC
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Underwater colonoscopy technique could make polyp removal safer and faster
Disease control CompletedThis study tested a new method called underwater endoscopic submucosal dissection (UESD) for removing large colon growths. Instead of using gas to inflate the colon, the doctor fills it with saline (salt water) to improve visibility and make the procedure easier. The trial involv…
Sponsor: University of Roma La Sapienza • Aim: Disease control
Last updated Jun 27, 2026 12:02 UTC
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Heart transplant drug may also fight skin cancer
Disease control CompletedThis study tested whether the drug everolimus can reduce new skin cancers in heart transplant patients who already had skin cancer. 175 participants received either everolimus or standard immunosuppressants. The goal was to see if everolimus lowers the number of new skin tumors n…
Phase 3 • Sponsor: Hospices Civils de Lyon • Aim: Disease control
Last updated Jun 27, 2026 08:05 UTC
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Old drug, new hope? thalidomide tested for rare mast cell cancer
Disease control CompletedThis study tested the drug thalidomide in people with systemic mastocytosis, a rare disease where too many mast cells build up in the body. The goal was to see if thalidomide could reduce the amount of disease in the bone marrow or other organs after 6 months. The trial included …
Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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Baby tamoxifen shows promise in preventing breast cancer recurrence
Prevention CompletedThis study follows up on women who took a low dose of tamoxifen (5 mg daily) for three years to see if it continues to prevent breast cancer over the long term. The original trial found a 42% reduction in breast cancer events. Researchers will also combine data from three similar…
Sponsor: Ente Ospedaliero Ospedali Galliera • Aim: Prevention
Last updated Jun 27, 2026 11:00 UTC
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8,000 volunteers help uncover colon polyp risks
Knowledge-focused CompletedThis study looked at why some people develop colorectal polyps (growths that can turn into cancer) and others do not. Researchers collected blood, urine, saliva, and tissue samples from over 8,000 adults getting a colonoscopy. They also gathered information about lifestyle and he…
Sponsor: Vanderbilt University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:04 UTC