Pleural mesothelioma

This early-stage trial is testing a new drug called IDE892, alone or with another drug (IDE397), in people with advanced solid tumors that have a specific genetic deletion (MTAP). The study aims to find safe doses and see if the drugs shrink tumors. It includes 260 adults with ca…

This study tests an oral medication (decitabine/cedazuridine) in people with BAP1 gene mutations who have early-stage mesothelioma that is not yet causing symptoms. The goal is to see if the drug can stop the cancer from growing or shrink it. About 9 participants will receive tre…

This study tests whether adding an experimental immunotherapy (fianlimab) to standard treatment (cemiplimab plus chemotherapy) can better control pleural mesothelioma, a rare and aggressive cancer of the lung lining. About 126 people who have not yet been treated will receive one…

This phase 2 trial tests a drug called ivonescimab in 38 people with pleural mesothelioma whose cancer has returned after immunotherapy and chemotherapy. The drug works by blocking blood vessel growth and boosting the immune system to fight cancer. The main goal is to see if the …

This study tests a drug called sacituzumab govitecan in 33 adults with mesothelioma that has come back or spread. Participants receive the drug until their disease worsens or side effects become too severe. The main goal is to see if the drug can shrink tumors and help control th…

This study tests an experimental oral drug called Alintegimod (7HP349) combined with two standard immunotherapies (ipilimumab and nivolumab) in people with advanced solid tumors like melanoma, lung, kidney, and liver cancers. The trial has two parts: first, finding a safe dose (p…

This early-phase trial tests whether adding the immunotherapy drug pembrolizumab and a special imaging technique during surgery can improve treatment for malignant pleural mesothelioma, a rare and aggressive lung cancer. About 20 adults with measurable disease will receive the co…

This study tests a new two-step treatment for people with malignant pleural mesothelioma, a rare and serious cancer of the lung lining. First, doctors use a special light therapy during a scope procedure to kill cancer cells. Then, patients receive an immunotherapy drug called ni…

This study is testing a new platform that uses advanced testing to get a complete picture of a person's tumor. The goal is to see if this detailed information can help doctors choose better treatments for patients with high-risk cancers like leukemia, multiple myeloma, and pancre…

This study looks at whether a surgery called partial pleurectomy (removing part of the lung lining) can help with symptoms and quality of life in people with advanced pleural mesothelioma that cannot be fully removed. About 30 participants will have the surgery and fill out sympt…

This observational study collects tumor tissue and blood cells from 200 people with advanced solid tumors like colorectal, lung, and pancreatic cancers. The goal is to understand how often tumors lose a specific marker (HLA) and to store participants' own T cells for potential fu…

This study follows 600 people with lung cancer or mesothelioma to track how their tumors evolve during and after treatment. Researchers collect blood, tissue, and imaging samples every few months to understand why some cancers come back or stop responding to therapy. The goal is …

This study is testing how to safely perform skin allergy tests in people receiving biotherapies for cancers and blood disorders. Researchers will find the highest concentration of each biotherapy that does not cause a skin reaction in 9 out of 10 patients. The goal is to establis…

This study is looking at tumor samples from 220 people with pleural or peritoneal mesothelioma, a rare cancer linked to asbestos. Researchers will analyze the genes and immune cells in these tumors to find patterns that could predict which treatments work best. The goal is to imp…