Paraplegia
MONDO:0003757Complete paralysis of the lower half of the body including both legs, often caused by damage to the spinal cord.
Also known as: severe or complete loss of motor function in the lower extremities and lower portions of the trunk
57 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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Halted gene therapy study raises questions for AMN patients
Disease control TerminatedThis early-stage trial tested a gene therapy called SBT101 for adrenomyeloneuropathy (AMN), a rare nerve disease that causes walking difficulties. Eight adults received either the therapy or a sham procedure. The study was terminated early, so we have limited data on safety and e…
Phase: PHASE1, PHASE2 • Sponsor: SwanBio Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 07:56 UTC
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Exoskeleton users at home: a peek into daily life
Knowledge-focused TerminatedThis study watched people with paraplegia who already use exoskeletons to see what daily tasks they can do at home. The goal was to find small home changes that could help them be more independent. Only 12 people took part, and the study was stopped early, so results are limited.
Sponsor: A.T. Still University of Health Sciences • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC
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Rare disease mystery: scientists watch AMN progress in hopes of finding a cure
Knowledge-focused TerminatedThis study followed 65 adult men with a rare inherited nerve disease called AMN (a form of spastic paraplegia) to understand how their symptoms change over time. Researchers collected data on walking ability and quality of life. The goal was to fill gaps in knowledge about the di…
Sponsor: SwanBio Therapeutics, Inc. • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:56 UTC