Paraplegia
MONDO:0003757Complete paralysis of the lower half of the body including both legs, often caused by damage to the spinal cord.
Also known as: severe or complete loss of motor function in the lower extremities and lower portions of the trunk
57 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsSub-types
Broader categories
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Mind over paralysis: Brain-Spine bridge aims to restore leg movement
Disease control OngoingThis study tests a device that reads brain signals and sends them to the spinal cord to help people with chronic spinal cord injury move their legs. Three participants will use the system during rehabilitation to see if it is safe and can improve walking. The goal is to create a …
Phase: NA • Sponsor: Ecole Polytechnique Fédérale de Lausanne • Aim: Disease control
Last updated Jun 27, 2026 13:07 UTC
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Can a smartwatch and coaching help paraplegics cut heart disease risk?
Disease control OngoingThis pilot study tests an 8-week program called REACH-SCI designed to help people with spinal cord injury (paraplegia) reduce the time they spend sitting. The program includes a wearable activity tracker, education, goal setting, one-on-one coaching, a peer support chat, and exer…
Phase: NA • Sponsor: Brunel University • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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AI boosts brain scan accuracy in massive new trial
Diagnosis ENROLLING_BY_INVITATIONThis study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…
Sponsor: Yaou Liu • Aim: Diagnosis
Last updated Jun 27, 2026 11:00 UTC
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New study tests workplace coaching to keep Parkinson's patients on the job
Symptom relief OngoingThis study tests a personalized workplace intervention for 124 Dutch workers with Parkinson's disease, cerebellar ataxia, hereditary spastic paraparesis, or slowly progressive neuromuscular/mitochondrial disorders. A trained facilitator helps employees and their managers identify…
Phase: NA • Sponsor: Radboud University Medical Center • Aim: Symptom relief
Last updated Jun 27, 2026 13:07 UTC
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Home exercise program shows promise for rare movement disorder
Symptom relief ENROLLING_BY_INVITATIONThis study tests whether a 12-week strength and functional exercise program, done at home via video calls with a physiotherapist, can improve walking, balance, and daily life in people with Hereditary Spastic Paraplegia (HSP). Twenty participants aged 16 to 70 will each experienc…
Phase: NA • Sponsor: Hospital de Clinicas de Porto Alegre • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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Electric rowing machine study for paralysis pulled before it began
Symptom relief TerminatedThis study planned to test whether training on a rowing machine that uses electrical stimulation to move the legs could improve fitness in adults with traumatic paraplegia. Participants would have trained for 6 months, but the trial was withdrawn before anyone enrolled, so no res…
Phase: NA • Sponsor: UGECAM Rhône-Alpes • Aim: Symptom relief
Last updated Jun 26, 2026 19:11 UTC
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Scientists hunt for clues in genes and body fluids to unlock ALS mysteries
Knowledge-focused OngoingThis study is observing 217 people with ALS and related conditions like frontotemporal dementia and hereditary spastic paraplegia. Researchers aim to connect each person's genetic makeup with their symptoms and find biological markers in blood and spinal fluid. No new treatments …
Sponsor: University of Miami • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Biggest ALS gene study aims to unlock disease secrets
Knowledge-focused OngoingThis study looks at people with ALS and similar diseases like frontotemporal dementia and hereditary spastic paraplegia. Researchers want to understand how genes affect the disease and find biological markers (biomarkers) to help develop future treatments. About 708 participants,…
Sponsor: University of Miami • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:00 UTC
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Massive study aims to unlock secrets of childhood nerve and muscle diseases
Knowledge-focused OngoingThis long-term study looks at children and adults with inherited nerve and muscle disorders that start early in life, like muscular dystrophy. Researchers will track symptoms over time and collect genetic samples from affected individuals, their family members, and healthy volunt…
Sponsor: National Institute of Neurological Disorders and Stroke (NINDS) • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:04 UTC
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Can a couple's lifestyle program reduce prostate cancer disparities?
Knowledge-focused OngoingThis study tests a lifestyle program for African American men who have finished prostate cancer treatment and their spouses or partners. The goal is to see if the program can improve quality of life, diet, physical activity, and partner support. Only 6 participants were enrolled,…
Phase: NA • Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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Couples in cancer care: how stress and support shape health behaviors
Knowledge-focused OngoingThis study follows 200 African American prostate cancer survivors and their partners to understand how daily stress, social support, and lifestyle choices like physical activity and diet affect each other. Participants wear an activity tracker and answer surveys on their smartpho…
Sponsor: M.D. Anderson Cancer Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:11 UTC
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New study tracks shoulder health in wheelchair users to prevent future pain
Knowledge-focused OngoingThis study follows 75 manual wheelchair users with spinal cord injuries over 3 to 5 years to see when and why shoulder problems start. Researchers use yearly MRIs and motion tracking to link daily activities to shoulder damage. The goal is to find ways to prevent shoulder pain an…
Sponsor: The University of Texas Medical Branch, Galveston • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:53 UTC