Paraplegia
MONDO:0003757Complete paralysis of the lower half of the body including both legs, often caused by damage to the spinal cord.
Also known as: severe or complete loss of motor function in the lower extremities and lower portions of the trunk
68 clinical trials for this condition and its sub-types, 47 tagged with Paraplegia itself.
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Sub-types of Paraplegia
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Hereditary spastic paraplegia 27 trials · 33 incl. sub-types
45 sub-types
- Complex hereditary spastic paraplegia 1 trial · 7 incl. sub-types Sub-types →
- Hereditary spastic paraplegia 50 3 trials
- Hereditary spastic paraplegia 3A 2 trials
- Hereditary spastic paraplegia 4 2 trials
- Hereditary spastic paraplegia 5A 2 trials
- Hereditary spastic paraplegia 47 1 trial
- Hereditary spastic paraplegia 51 1 trial
- Hereditary spastic paraplegia 52 1 trial
- Hereditary spastic paraplegia 7 1 trial
- ADAR-related hereditary spastic paraplegia 0 trials
- Charcot-Marie-Tooth disease type 5 0 trials
- IFIH1-related hereditary spastic paraplegia 0 trials
- RNASEH2B-related hereditary spastic paraplegia 0 trials
- Early-onset progressive neurodegeneration-blindness-ataxia-spasticity syndrome 0 trials
- Hereditary spastic paraplegia 10 0 trials
- Hereditary spastic paraplegia 13 0 trials
- Hereditary spastic paraplegia 14 0 trials
- Hereditary spastic paraplegia 16 0 trials
- Hereditary spastic paraplegia 2 0 trials
- Hereditary spastic paraplegia 30 0 trials Sub-types →
- Hereditary spastic paraplegia 31 0 trials
- Hereditary spastic paraplegia 33 0 trials
- Hereditary spastic paraplegia 35 0 trials
- Hereditary spastic paraplegia 48 0 trials
- Hereditary spastic paraplegia 56 0 trials
- Hereditary spastic paraplegia 6 0 trials
- Hereditary spastic paraplegia 77 0 trials
- Macrocephaly-spastic paraplegia-dysmorphism syndrome 0 trials
- Mast syndrome 0 trials
- Pure hereditary spastic paraplegia 0 trials Sub-types →
- Pure or complex hereditary spastic paraplegia 0 trials
- Spastic paraplegia 72b, autosomal recessive 0 trials
- Spastic paraplegia 79A, autosomal dominant, with ataxia 0 trials
- Spastic paraplegia 80, autosomal dominant 0 trials
- Spastic paraplegia 81, autosomal recessive 0 trials
- Spastic paraplegia 82, autosomal recessive 0 trials
- Spastic paraplegia 83, autosomal recessive 0 trials
- Spastic paraplegia 87, autosomal recessive 0 trials
- Spastic paraplegia 88, autosomal dominant 0 trials
- Spastic paraplegia 89, autosomal recessive 0 trials
- Spastic paraplegia 90A, autosomal dominant 0 trials
- Spastic paraplegia 90B, autosomal recessive 0 trials
- Spastic paraplegia 91, autosomal dominant, with or without cerebellar ataxia 0 trials
- Spastic paraplegia 92, autosomal recessive 0 trials
- Spastic paraplegia 93, autosomal recessive 0 trials
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Brown-Sequard syndrome 0 trials
Most studied deeper sub-types
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Spinal zaps + robotic steps: a new hope for walking after injury?
Disease control CompletedThis study tests whether applying noninvasive electrical stimulation to the spinal cord before robotic gait training can improve walking recovery in people with motor-incomplete spinal cord injury. Participants receive 40 sessions of either standing or lying stimulation followed …
Sponsor: City University of New York • Aim: Disease control
Last updated Aug 20, 2026 00:00 UTC
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Spinal cord stimulation may help restore movement after paralysis
Disease control CompletedThis pilot study tests whether electrical stimulation of the spinal cord can improve motor function and reduce spasticity in people with spinal cord injury. Participants receive epidural and dorsal root stimulation during 10 rehabilitation sessions. The study measures changes in …
Sponsor: Peter J. Grahn, Ph.D. • Aim: Disease control
Last updated Jul 18, 2026 00:00 UTC
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Can electrical leg biking and diet beat metabolic syndrome in spinal cord injury?
Disease control CompletedThis study tested whether a home exercise program using electrical stimulation to move the legs, combined with a personalized diet, could improve body composition and metabolism in adults with spinal cord injury. Twenty-six participants were assigned to either exercise plus diet …
Sponsor: University of Miami • Aim: Disease control
Last updated Jun 27, 2026 08:06 UTC
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Could a cocktail of three drugs tame a rare paralyzing disease?
Disease control CompletedThis phase 2 trial tested three drugs—Xenbilox, Tahor, and resveratrol—in 12 adults with SPG5, a rare genetic condition causing progressive leg weakness. The goal was to lower levels of a toxic cholesterol byproduct called 27-hydroxycholesterol. Each drug was taken for 2 months, …
Phase 2 • Sponsor: Institut National de la Santé Et de la Recherche Médicale, France • Aim: Disease control
Last updated Jun 26, 2026 12:36 UTC
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New scale could help predict fall risk for hospital patients in turkey
Diagnosis CompletedThis study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…
Sponsor: Sisli Hamidiye Etfal Training and Research Hospital • Aim: Diagnosis
Last updated Jun 27, 2026 09:08 UTC
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Robot suit helps MS patients walk again – small study shows promise
Symptom relief CompletedThis study tested a robotic exoskeleton called Atalante to see if it is easy and safe for people with multiple sclerosis (MS) to use. 15 adults with MS who had trouble walking tried the device. The goal was to see if the suit could help them walk better and if they liked using it…
Sponsor: Multiple Sclerosis Center of Catalonia • Aim: Symptom relief
Last updated Jul 11, 2026 00:00 UTC
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New wheelchair helps paralyzed veterans stand and roll
Symptom relief CompletedThis study tested a special wheelchair that lets people with spinal cord injuries stand up and move around at the same time. The goal was to see if using this chair at home and in the community helps them stand more often and feel more satisfied with their daily activities. Twent…
Sponsor: VA Office of Research and Development • Aim: Symptom relief
Last updated Jun 27, 2026 12:05 UTC
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Sound waves aim to calm spastic muscles in spinal injury patients
Symptom relief CompletedThis pilot study tested whether a non-invasive treatment called extracorporeal shockwave therapy (ESWT) can safely reduce spasticity—muscle stiffness and spasms—in people with chronic spinal cord injury. Five participants received ESWT or a sham treatment, and researchers measure…
Sponsor: Kessler Foundation • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Carbon braces may help kids with nerve conditions walk better
Symptom relief CompletedThis study tested prefabricated carbon fiber ankle-foot orthoses (AFOs) in 65 children and teenagers with conditions like cerebral palsy, spina bifida, or spinal cord injuries that affect walking. Researchers measured stride length, walking speed, and user satisfaction by compari…
Sponsor: Otto Bock France SNC • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC
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Which exoskeleton do therapists prefer? a Head-to-Head comparison
Knowledge-focused CompletedThis study asks whether physiotherapists and physical education instructors are more satisfied with certain exoskeleton models used for gait training in rehabilitation. A group of 14 experienced professionals will test three different devices and rate their usability. The goal is…
Sponsor: University of Sao Paulo General Hospital • Aim: Knowledge-focused
Last updated Aug 19, 2026 00:00 UTC
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Smooth transitions: a study on how disabled youth navigate adult healthcare
Knowledge-focused CompletedThis study looks at how young people with conditions like cerebral palsy, spina bifida, and spinal cord injury move from pediatric to adult medical care. Researchers will review medical records from the past 10 years and interview patients who have already made the switch. The go…
Sponsor: Centre Hospitalier Universitaire de Saint Etienne • Aim: Knowledge-focused
Last updated Jul 18, 2026 00:00 UTC
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Remote coaching boosts Clinicians' wheelchair training skills
Knowledge-focused CompletedThis study tested whether a remote training program helps rehabilitation professionals teach manual wheelchair users how to use their chairs more safely and effectively. 235 clinicians took part and were split into three groups: one received remote feedback, one did structured se…
Sponsor: University of Pittsburgh • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:36 UTC
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Robot suit helps stroke and spinal injury patients walk again – small study shows promise
Knowledge-focused CompletedThis pilot study tested a wearable robotic exoskeleton called EksoNR in 5 people with stroke, spinal cord injury, cerebellar ataxia, or spastic paraplegia. The goal was to see if using the device for gait training in an outpatient setting is safe, tolerable, and feasible. Researc…
Sponsor: Somogy Megyei Kaposi Mór Teaching Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:13 UTC
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Study reveals key links between arm endurance and pain in paraplegia
Knowledge-focused CompletedThis study looked at 32 wheelchair users with paraplegia to understand how arm endurance, fine motor skills, and symptoms like pain and weakness are connected. Participants completed tests of arm function and reported their symptoms. The goal was to find relationships that could …
Sponsor: Hacettepe University • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC
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Brain complications after emergency aortic surgery linked to longer ICU stays
Knowledge-focused CompletedThis study reviewed medical records of 274 adults who had emergency surgery for a torn aorta (aortic dissection). Researchers looked at how often patients had brain complications like stroke or coma after surgery and whether those complications led to longer stays in the intensiv…
Sponsor: China Medical University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC