Oral cavity cancer
MONDO:0005515A primary or metastatic malignant neoplasm involving the oral cavity. The majority are squamous cell carcinomas.
Also known as: cancer of oral cavity, malignant mouth neoplasm, malignant mouth tumor, malignant mouth tumour, malignant neoplasm of mouth, malignant neoplasm of oral cavity, malignant neoplasm of the mouth, malignant oral cavity neoplasm
3140 clinical trials for this condition and its sub-types, 42 tagged with Oral cavity cancer itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Oral cavity cancer
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Oral cavity carcinoma 16 trials · 202 incl. sub-types
9 sub-types
- Oral cavity squamous cell carcinoma 141 trials · 156 incl. sub-types Sub-types →
- Salivary gland carcinoma 26 trials · 36 incl. sub-types Sub-types →
- Oral cavity carcinoma in situ 5 trials Sub-types →
- Tongue carcinoma 4 trials
- Carcinoma of lip 0 trials · 2 incl. sub-types Sub-types →
- Carcinoma of hard palate 1 trial
- Carcinoma of soft palate 1 trial
- Intraoral basal cell carcinoma 0 trials
- Oral cavity mucoepidermoid carcinoma 0 trials Sub-types →
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Salivary gland cancer 62 trials · 81 incl. sub-types
3 sub-types
- Salivary gland carcinoma 26 trials · 36 incl. sub-types Sub-types →
- Major salivary gland cancer 7 trials · 16 incl. sub-types Sub-types →
- Malignant tumor of minor salivary gland 0 trials Sub-types →
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Tongue cancer 26 trials · 35 incl. sub-types
2 sub-types
- Tongue squamous cell carcinoma 9 trials · 13 incl. sub-types Sub-types →
- Tongue carcinoma 4 trials
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Lip cancer 12 trials · 15 incl. sub-types
3 sub-types
- Carcinoma of lip 0 trials · 2 incl. sub-types Sub-types →
- Lower lip cancer 1 trial
- Upper lip cancer 0 trials
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Cheek mucosa cancer 1 trial · 2 incl. sub-types
1 sub-type
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Gingival cancer 1 trial · 2 incl. sub-types
2 sub-types
- Upper gum cancer 2 trials
- Lower gum cancer 0 trials
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Retromolar area cancer 1 trial
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Hard palate cancer 0 trials · 1 incl. sub-types
1 sub-type
- Carcinoma of hard palate 1 trial
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Soft palate cancer 0 trials · 1 incl. sub-types
2 sub-types
- Carcinoma of soft palate 1 trial
- Uvula cancer 0 trials
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Oral rhabdomyosarcoma 0 trials
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Vestibule of mouth cancer 0 trials
1 sub-type
Most studied deeper sub-types
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Cialis and keytruda together against head and neck cancer: small trial shows promise?
Disease control CompletedThis completed phase II study tested a combination of two drugs—tadalafil (Cialis) and pembrolizumab (Keytruda)—in 7 adults with advanced head and neck cancer that had spread or come back. The goal was to see if the combination was safe and could help control the disease. Because…
Phase 2 • Sponsor: University of California, San Diego • Aim: Disease control
Last updated Jun 27, 2026 09:04 UTC
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New drug combo shows promise for Tough-to-Treat head and neck cancer
Disease control CompletedThis study tested a combination of two drugs, pembrolizumab and cetuximab, in 78 people with advanced head and neck cancer that had returned or spread. The goal was to see if the combination could shrink tumors or slow the disease. Participants were grouped based on whether they …
Phase 2 • Sponsor: University of California, San Diego • Aim: Disease control
Last updated Jun 27, 2026 09:00 UTC
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Radiation after surgery may keep early oral cancer at bay
Disease control CompletedThis study looked at whether giving radiation therapy after surgery can prevent early-stage oral cancer from coming back. It included 392 patients with tumors at least 5mm thick. Half received radiation, half were just watched. The main goal was to see if radiation reduced local …
Sponsor: Tata Memorial Hospital • Aim: Disease control
Last updated Jun 27, 2026 08:11 UTC
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Immunotherapy boosts standard treatment for head and neck cancer in early trial
Disease control CompletedThis early-phase trial tested whether adding the immunotherapy drug pembrolizumab to standard chemoradiation is safe and effective for people with advanced head and neck cancer. 59 participants received pembrolizumab before, during, and after their regular treatment. The goal was…
Phase 1 • Sponsor: Sanford Health • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Can a laser scan catch mouth cancer before it spreads?
Diagnosis CompletedThis trial tests a device that uses a laser to scan the inside of the mouth and help detect pre-cancer and cancer. Currently, doctors rely on their eyes to decide where to take a biopsy, which can miss early signs. The device collects molecular information from the tissue, and th…
Sponsor: King's College London • Aim: Diagnosis
Last updated Aug 29, 2026 00:00 UTC
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Can a single tracer light up cancer's first stop? a trial puts a hybrid dye-and-radioactive marker to the test.
Diagnosis CompletedThis trial tests whether a new hybrid tracer, ICG-99mTc-nanoscan, can replace the standard tracer for sentinel node biopsy in people with penile cancer, melanoma, or oral cancer. The hybrid tracer combines a fluorescent dye with a radioactive marker, potentially allowing surgeons…
Sponsor: The Netherlands Cancer Institute • Aim: Diagnosis
Last updated Jul 24, 2026 00:00 UTC
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Exercise and diet combo tested for head and neck cancer recovery
Symptom relief CompletedThis study tests whether a program combining resistance training and a Mediterranean diet is practical and helpful for people with head and neck cancer undergoing radiation. Forty participants will receive supervised exercise sessions and pre-made meals, plus dietary coaching. Th…
Sponsor: H. Lee Moffitt Cancer Center and Research Institute • Aim: Symptom relief
Last updated Sep 19, 2026 00:00 UTC
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New combo could delay painful mouth sores in cancer radiation
Symptom relief CompletedThis study tested whether adding thalidomide to glutamine can delay the onset of severe mouth sores caused by radiation therapy. 138 oral cancer patients were randomly assigned to receive either the combination or glutamine alone during their radiation treatment. The main goal wa…
Phase 3 • Sponsor: Air Force Military Medical University, China • Aim: Symptom relief
Last updated Jul 03, 2026 00:00 UTC
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New gel may cut pain and bleeding after mouth surgery
Symptom relief CompletedThis study tested whether a gel called PuraBond, applied to the surgical wound during mouth or throat surgery, can reduce pain and bleeding afterward. 73 patients were randomly assigned to receive the gel or not. Researchers measured pain levels over 30 days and tracked complicat…
Sponsor: University of Liverpool • Aim: Symptom relief
Last updated Jun 26, 2026 18:17 UTC