Opioid-induced constipation

This study tested whether tranexamic acid, a drug that helps blood clot, can lower the chance of infection after gastrointestinal surgery. Over 3,300 adults at higher risk for complications took part. The goal was to see if the drug reduces surgical site infections compared to a …

This pilot study tested a drug called TD-1211 in 95 people who had constipation from taking opioid pain medications. The main goal was to see if the drug was safe and tolerable. Researchers also looked at whether it increased the number of complete and spontaneous bowel movements…

This study tested a drug called TD-1211 in healthy volunteers and people with constipation caused by opioid painkillers. The goal was to see if it is safe and helps with bowel movements. Participants took different doses of TD-1211 or a placebo, and researchers monitored their sa…

This study tested a drug called TD-1211 in 217 adults who have constipation because of opioid painkillers. The goal was to see if it safely increases the number of complete spontaneous bowel movements each week. Participants took either the study drug or a placebo for several wee…

This study tested a new drug called TD-1211 in 69 adults who had constipation because of opioid painkillers. The goal was to see if the drug is safe and helps people have more bowel movements. Participants stopped using other laxatives during the study to see how well TD-1211 wor…

This study tested a 12-week online mind-body program for adults with chronic conditions like heart failure, cancer, and liver disease. The program included mindful movement, meditation, breathwork, and coping skills. Researchers measured changes in anxiety, depression, fatigue, a…

This study tested whether electroacupuncture (a type of acupuncture with mild electric pulses) can safely relieve constipation caused by opioid painkillers in people with cancer. 92 patients took part in a single-blind trial where some received real electroacupuncture and others …

This study looked at whether adding fiber to liquid food given through a tube can prevent constipation caused by strong painkillers in ICU patients on breathing machines. Researchers compared fiber-enriched and fiber-free formulas in 80 adults. The goal was to see if fiber helps …

This study looked at how the body processes TD-1211, a drug for opioid-induced constipation. Ten healthy men received a single dose of the drug with a radioactive tracer to track its absorption, distribution, and elimination. The goal was to understand the drug's behavior, not to…