Neurogenic bowel

This early-phase study tests whether a combination of two medications (neostigmine and glycopyrrolate) can be delivered through the skin using a mild electric current to help people with spinal cord injury have a bowel movement. Participants first receive the medication intraveno…

This study tested a surgery to help children who have trouble controlling both their bowel and bladder due to nerve problems. Thirty children who did not get better with other treatments had the surgery. The researchers looked at how safe the surgery was and if it improved the ch…

This early study tested a wireless patch that uses a tiny electric current to push two drugs (neostigmine and glycopyrrolate) through the skin and into the blood. The goal is to help people with spinal cord injury have predictable bowel movements without needles. Only 2 healthy v…

This study tested a new device called MOWOOT for people with chronic constipation. 86 adults who already used standard treatment (trans-anal irrigation) tried the MOWOOT device to see if it improved their symptoms and quality of life. The goal was to compare the new device's effe…

This small study tested whether training with a robotic exoskeleton (a wearable robot suit) can help improve bowel function in people with spinal cord injury. Ten adults with long-term spinal cord injury used the exoskeleton in a supervised program. Researchers measured changes i…

This study tested whether using a device that electrically stimulates the abdominal muscles can help people with spinal cord injury manage their bowel movements more quickly and comfortably. 36 adults with injuries at or above T12 were randomly assigned to receive real or low-dos…

This study tested a new, smaller bowel irrigation device called Navina Mini in 27 children and teens aged 3 to 17 with bowel problems like severe constipation or leakage. The goal was to see if the device is safe, easy to use, and improves bowel emptying and satisfaction. Results…

This study looked at how spinal cord epidural stimulation affects bladder, bowel, and blood pressure control in 61 adults with spinal cord injury. Researchers monitored participants in a lab and at home to understand autonomic dysreflexia and test stimulation as a therapy. The go…

This early-phase trial in 13 healthy volunteers measures how two drugs, neostigmine and glycopyrrolate, enter the bloodstream when given through a skin patch using a mild electric current (iontophoresis) compared to an IV. The goal is to see if this needle-free method could one d…