Myelomeningocele
MONDO:0019773Myelomeningocele is the most severe form of spina bifida. It happens when parts of the spinal cord and nerves come through the open part of the spine. It causes nerve damage and other disabilities. Seventy to ninety percent of children with this condition also have too much fluid on their brains (hydrocephalus). This happens because fluid that protects the brain and spinal cord is unable to drain like it should. The fluid builds up, causing pressure and swelling. Without treatment, a persons head grows too big, and theymay have brain damage. Other disorders of the spinal cord may be seen, including syringomyelia and hip dislocation. The cause of myelomeningocele is unknown. However, low levels of folic acid in a woman's body before and during early pregnancy is thought to play a part in this type of birth defect.
Also known as: meningomyelocele
26 clinical trials for this condition and its sub-types.
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Broader categories
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New hope for toddlers with bladder nerve damage: mirabegron trial launches
Disease control OngoingThis study tests a liquid medicine called mirabegron in children aged 6 months to 3 years who have bladder problems due to nerve damage (neurogenic detrusor overactivity). The goal is to see if the medicine helps the bladder hold more urine safely, reducing leaks and pressure. Ch…
Phase: PHASE3 • Sponsor: Astellas Pharma Global Development, Inc. • Aim: Disease control
Last updated Jun 27, 2026 14:00 UTC
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Womb surgery breakthrough: two methods to fix spina bifida before birth
Disease control OngoingThis study tests two ways to surgically repair spina bifida in the womb using a tiny camera. The goal is to close the spinal defect and reverse brain changes caused by the condition. About 110 pregnant women carrying babies with spina bifida will take part. The two methods are co…
Phase: NA • Sponsor: University of Southern California • Aim: Disease control
Last updated Jun 27, 2026 12:29 UTC
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Keyhole surgery in the womb could fix spina bifida with fewer risks
Disease control OngoingThis study tests a minimally invasive fetoscopic surgery to repair spina bifida in unborn babies. The goal is to close the spinal defect and reverse brain herniation while reducing risks like uterine rupture and preterm birth that come with open fetal surgery. Thirty pregnant wom…
Phase: NA • Sponsor: Johns Hopkins University • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Patch may boost fetal spina bifida repair, early trial hints
Disease control OngoingThis study tests two minimally invasive fetal surgery techniques for repairing neural tube defects (spina bifida) in the womb. One method uses a Durepair patch to reinforce the repair, while the other does not. Researchers aim to see if the patch leads to a thicker repair and few…
Phase: PHASE1 • Sponsor: Baylor College of Medicine • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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Umbilical cord patch used in womb to repair spina bifida
Disease control OngoingThis study tests a new way to repair spina bifida before birth using a tiny camera and a patch made from donated human umbilical cord tissue. The patch is placed over the spinal cord to create a watertight seal, which may reduce problems after birth. The trial includes 50 pregnan…
Phase: NA • Sponsor: The University of Texas Health Science Center, Houston • Aim: Disease control
Last updated Jun 26, 2026 12:45 UTC
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AI boosts brain scan accuracy in massive new trial
Diagnosis ENROLLING_BY_INVITATIONThis study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…
Sponsor: Yaou Liu • Aim: Diagnosis
Last updated Jun 27, 2026 11:00 UTC
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New program aims to help adults with spina bifida navigate health challenges
Symptom relief OngoingThis pilot study tests a program called ALIGN, designed to help adults with spina bifida improve how they manage health tasks like coordinating care and handling medications. The program includes six virtual group sessions and one individual session with a clinician. Researchers …
Phase: NA • Sponsor: University of Pittsburgh • Aim: Symptom relief
Last updated Jun 27, 2026 13:02 UTC
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Magnetic pulses could help kids with spina bifida control their bladders
Symptom relief OngoingThis study tests whether a non-invasive device that delivers pulsed electromagnetic fields can improve bladder function in 40 children aged 4-12 with myelomeningocele (a form of spina bifida). The treatment aims to stimulate nerves controlling the bladder, potentially reducing in…
Phase: NA • Sponsor: South Valley University • Aim: Symptom relief
Last updated Jun 27, 2026 08:04 UTC
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Timing of breathing tube removal may impact newborn spina bifida recovery
Knowledge-focused OngoingThis study examines whether removing the breathing tube (extubation) in the operating room versus later in the intensive care unit improves outcomes for newborns undergoing surgery for myelomeningocele, a type of spina bifida. Researchers will review records of 60 babies to compa…
Sponsor: Gaziantep City Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 11:00 UTC
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New tool lets kids with spina bifida choose their own incontinence goals
Knowledge-focused OngoingThis study is creating a new tool for children with spina bifida and their doctors to work together on setting personal goals for managing bladder and bowel leakage. The goal is to improve the child's quality of life by focusing on what matters most to them, rather than just medi…
Phase: NA • Sponsor: Indiana University • Aim: Knowledge-focused
Last updated Jun 27, 2026 07:52 UTC