Meningitis

This study looked at whether a booster dose of the meningitis B vaccine (Bexsero) works well and is safe for healthy people aged 10 to 20. It included 312 participants who either got the vaccine as babies or had never received it. The goal was to see if the booster triggers a str…

This study tested a new vaccine (NmCV-5) to protect infants against meningitis, a serious infection of the brain and spine. About 1,325 healthy infants in Mali received either the new vaccine or a standard one at 9 or 15 months old. The goal was to see if the new vaccine works as…

This study looked at whether giving the meningitis B vaccine (Bexsero) and the pneumonia vaccine (PCV13) along with routine baby shots is safe and works well. About 1,200 healthy infants aged 6 to 12 weeks took part. Researchers checked for side effects like pain, redness, fever,…

This study tested a new vaccine called BK1310 in 267 healthy infants to see if it protects against tetanus, diphtheria, pertussis, polio, and bacterial meningitis as well as existing vaccines. Infants received three doses, and researchers measured their immune responses. The goal…

This study tested a new rapid diagnostic panel called QIAstat-Dx that can detect 15 different bacteria, viruses, and fungi causing meningitis and encephalitis in just one hour. Researchers compared its accuracy against standard lab tests using 170 stored spinal fluid samples. If …

This study aimed to create a quick, simple test to diagnose tuberculous meningitis (TBM) in children. TBM is a severe form of TB that affects the brain and is hard to detect with current methods, especially in places with limited resources. Researchers tested 51 inflammatory mark…

This trial is testing the safety of the Menhycia® vaccine in about 3,000 healthy 3-month-old infants who have not yet received any epidemic meningitis vaccine. The infants will receive three doses of the vaccine at least one month apart, with an optional booster at 12 months of a…

This trial is testing an experimental vaccine called Menhycia, designed to protect against four types of meningococcal bacteria (A, C, Y, and W135) that can cause meningitis and bloodstream infections. The study involves about 1,480 healthy adults aged 18 to 55, who will receive …

This trial is testing an experimental vaccine designed to protect against four strains of the bacteria that cause meningococcal meningitis, a serious infection of the brain and spinal cord. The study involves around 840 participants aged 7 to 17, who will receive either the new v…

This trial tests whether adding music therapy to standard rehabilitation helps people recover better after serious neurological injuries like stroke, brain injury, or spinal cord damage. About 75 participants aged 16-80 will be randomly assigned to receive either music therapy or…

This study tested whether giving midazolam in the mouth (buccal) works as well as a shot in the thigh (intramuscular) to stop seizures in children aged 6 months to 12 years. 90 children were randomly assigned to one of the two methods. The main goal was to see if seizures stopped…

This study looked at how different meningococcal vaccines affect B cells, the white blood cells that produce antibodies. Researchers gave 20 healthy adults aged 30-70 either a polysaccharide or conjugate vaccine and then measured their B cell responses. The goal was to understand…

This study looked for hidden immune system problems in adults who get frequent or severe bacterial infections, like pneumonia or meningitis. Researchers screened 120 adults aged 18-65 to see how many had an undiagnosed primary immunodeficiency. The goal was to find out if these c…

This study looked at how gadolinium, a dye used in MRI scans, changes the QSM signal in the brain's white matter. 73 patients with inflammatory central nervous system conditions had MRI scans before and after receiving gadolinium. The goal was to measure any differences in the si…

This study looked at whether epidural or spinal anesthesia during childbirth leads to more infections in women with primary immunodeficiencies (weak immune systems). Researchers tracked 30 women from a national registry for 28 days after delivery to see if they developed serious …

This study examined 151 mothers and their newborns to understand why some babies get a severe infection from a specific strain of Group B Strep (GBS). Researchers tested samples from the mother's vagina, breast milk, and the baby's mouth and stool. They hope to find how gut bacte…

This completed study looked at how group B streptococcus (GBS) bacteria colonize the digestive tract of newborns. Researchers followed nearly 950 mothers and their babies, taking samples from the mother and umbilical cord at birth. The goal was to see if a specific, more dangerou…