Mac-Leod-Swyer-James-Syndrome
MONDO:0800120A rare lung condition characterized by often predominantly unilateral lung hyperlucency and air trapping. The condition is a post-infectious form of bronchiolitis obliterans and typically follows a viral respiratory infection in infancy and childhood. Adenovirus infection is considered the most usual epidemiology. In SJS, the involved lung or portion of the lung does not grow normally and is slightly smaller than the opposite lung: in particular, peripheral branches of the pulmonary vessels do not develop, and vasculature is arreseted at the stage at which the infection occurred. Patients respond well to management with bronchodilators, even though this is not primarily a bronchial abnormality.
Also known as: SJS, Swyer-James-(Macleod)-Syndrome
24 clinical trials for this condition and its sub-types.
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Could a simple breath test spot hidden diseases early?
Diagnosis CompletedThis study is testing a portable, non-invasive breath analyzer that measures tiny particles in exhaled breath to screen for conditions like type 2 diabetes, liver disease, kidney disease, and lung disease. Researchers will enroll healthy volunteers and people with known diagnoses…
Sponsor: Respyr • Aim: Diagnosis
Last updated Jun 27, 2026 13:07 UTC
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Radiation-Free lung scans for kids? new MRI shows promise
Diagnosis CompletedThis study tested a new MRI technique that can take pictures of children's lungs without using radiation or injecting contrast dye. 72 children aged 6-16 had both a standard CT scan and this new MRI. The goal was to see if the MRI could produce clear images of the lungs, potentia…
Phase: NA • Sponsor: Assistance Publique - Hôpitaux de Paris • Aim: Diagnosis
Last updated Jun 26, 2026 15:40 UTC
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New hope for preventing Post-Surgery confusion in seniors
Symptom relief CompletedThis study tested whether giving a small amount of s-ketamine during chest surgery could reduce the risk of postoperative delirium (sudden confusion) in patients aged 60 and older. Over 500 participants were randomly assigned to receive either s-ketamine or another drug (dexmedet…
Phase: EARLY_PHASE1 • Sponsor: Affiliated Cancer Hospital & Institute of Guangzhou Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 12:28 UTC
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Ice your pain away: nerve freezing may cut opioid use after lung surgery
Symptom relief CompletedThis study tested freezing the nerves between the ribs during robot-assisted lung surgery to see if it reduces pain and the need for painkillers afterward. 33 adults having lung surgery were randomly assigned to get the nerve freeze or standard pain medicine. Researchers tracked …
Phase: PHASE4 • Sponsor: Medical College of Wisconsin • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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Could a tiny dose of muscle relaxant make lung scopes safer?
Symptom relief CompletedThis study looked at whether giving a low dose of a muscle relaxant (rocuronium) during bronchoscopy—a procedure where a tube is inserted into the lungs—could reduce complications like throat spasms and coughing. 153 adults having elective bronchoscopy were split into two groups:…
Phase: NA • Sponsor: Harbin Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 09:09 UTC
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Scientists examine lung cells to understand chronic lung disease
Knowledge-focused CompletedThis study looked at immune cells called alveolar macrophages in the lungs of 18 people with non-infectious lung diseases. Researchers used a technique called flow cytometry to study the surface proteins on these cells. The goal was to better understand the role of these cells in…
Sponsor: Rennes University Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:01 UTC
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Could a stroll beat a sprint for oxygen testing?
Knowledge-focused CompletedThis study looked at 93 people with lung disease who get short of breath when active. Participants did two 6-minute walk tests: one at their fastest pace and one at their normal walking speed. The goal was to see if the normal-speed test gives a more accurate picture of when they…
Phase: NA • Sponsor: Hampshire Hospitals NHS Foundation Trust • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:09 UTC
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Hospital dietitians boost nutrition in lung patients, study finds
Knowledge-focused CompletedThis study tested whether having a dietitian help patients with lung disease order meals during a hospital stay could improve their nutrition and reduce the chance of being readmitted after discharge. 41 patients at nutritional risk took part. Researchers measured daily food inta…
Sponsor: Gødstrup Hospital • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:05 UTC