Intestinal infectious disease

This study tests a new vaccine (IP-QSV) designed to protect against four types of Shigella bacteria, which cause severe diarrhea. The trial will include 370 healthy adults, children, and infants in Mali. Researchers will check if the vaccine is safe and triggers a strong immune r…

This early-stage study tests a new oral cholera vaccine called DuoChol in 60 healthy adults aged 18 to 45 in Sweden. Participants will receive two doses of either DuoChol or an existing vaccine (Dukoral) to compare safety and immune response. The goal is to gather initial data to…

This study follows up on African children who received an experimental Shigella vaccine in earlier studies. Researchers will take blood samples 1, 2, and 3 years after the last vaccine dose to see how long the immune protection lasts. No new vaccines are given in this study. The …

This study tests whether adding a probiotic called Lacticaseibacillus rhamnosus GG to standard care (like rehydration fluids) can shorten the duration of acute infectious diarrhea in children. About 480 kids aged 1 month to 10 years in Turkey will take part. Half will get the pro…

This study looks at whether a special oral nutritional supplement, combined with dietary counseling, can improve growth in children who are not growing as expected. About 216 children will be randomly assigned to receive either the supplement plus counseling or counseling alone. …