Intermittent vascular claudication
MONDO:0005295A symptom complex characterized by pain and weakness in skeletal muscle group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial stenosis; muscle ischemia; and accumulation of lactate.
35 clinical trials for this condition and its sub-types.
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Air cuffs boost walking in blocked leg arteries?
Symptom relief OngoingThis study tests whether wearing inflatable leg cuffs (intermittent pneumatic compression) for six months can improve walking distance in people with peripheral artery disease (PAD). Some participants also combine the cuffs with walking exercise. The goal is to see if the cuffs h…
Phase: NA • Sponsor: Northwestern University • Aim: Symptom relief
Last updated Jun 27, 2026 13:03 UTC
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Could a simple supplement mix help leg pain sufferers walk pain-free?
Symptom relief OngoingThis early study tests whether a combination of arginine, tetrahydrobiopterin, and vitamin C can boost nitric oxide levels in the blood and help people with peripheral artery disease walk longer without pain. Ten participants will take the therapy and be monitored for changes in …
Phase: PHASE1 • Sponsor: Louis Messina • Aim: Symptom relief
Last updated Jun 27, 2026 12:07 UTC
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Heat therapy for leg pain study pulled before starting
Knowledge-focused TerminatedThis study was designed to see if a device called AirGlove, which applies heat, could improve blood flow in the legs of people with peripheral arterial disease (PAD). It planned to include healthy volunteers and people with PAD who experience leg pain when walking. However, the s…
Phase: NA • Sponsor: Norfolk and Norwich University Hospitals NHS Foundation Trust • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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New registry monitors VBX stent graft in Real-World use
Knowledge-focused OngoingThis study is a registry that collects safety and performance data on the GORE® VIABAHN® VBX Stent Graft when used in peripheral vessels. It involves 280 adults who need this device to treat peripheral vascular disease. The goal is to see how well the stent graft works and if the…
Sponsor: W.L.Gore & Associates • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC
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Arm workouts may boost leg circulation in PAD patients, new study hints
Knowledge-focused ENROLLING_BY_INVITATIONThis study looks at how arm crank exercise (like pedaling with your arms) changes blood flow in people with peripheral artery disease (PAD) compared to healthy adults. Researchers will measure blood vessel function and oxygen levels in the calf before and after exercise. The goal…
Phase: NA • Sponsor: University of Nove de Julho • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:07 UTC