Intermittent vascular claudication
MONDO:0005295A symptom complex characterized by pain and weakness in skeletal muscle group associated with exercise, such as leg pain and weakness brought on by walking. Such muscle limpness disappears after a brief rest and is often relates to arterial stenosis; muscle ischemia; and accumulation of lactate.
35 clinical trials for this condition and its sub-types.
Follow this condition — get notified about new trialsBroader categories
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Laser catheter shows promise for unclogging leg arteries
Disease control CompletedThis study looked at how well the AURYON atherectomy device works for people with peripheral artery disease (PAD), where leg arteries become blocked. The device uses a laser to vaporize plaque and restore blood flow. Researchers followed 102 patients to see if the procedure was s…
Sponsor: Angiodynamics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:34 UTC
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Can a heart pill help you walk longer without pain?
Symptom relief CompletedThis study tested whether ramipril, a common blood pressure medicine, can improve walking distance in people with intermittent claudication (leg pain due to narrowed arteries). Researchers planned to enroll 78 adults with stable leg pain, giving half ramipril and half a placebo. …
Phase: PHASE4 • Sponsor: Hull University Teaching Hospitals NHS Trust • Aim: Symptom relief
Last updated Jun 27, 2026 08:05 UTC
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Shock therapy for leg pain? tiny device may help PAD patients move more
Symptom relief CompletedThis study tested whether a small device called TENS, which sends mild electrical pulses to the skin, could reduce leg pain during walking in people with peripheral artery disease (PAD). It also looked at adding a patient education program to encourage more physical activity. The…
Phase: NA • Sponsor: Glasgow Caledonian University • Aim: Symptom relief
Last updated Jun 27, 2026 07:53 UTC
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Arm workouts may boost leg oxygen in PAD patients, study finds
Knowledge-focused CompletedThis study looked at 26 people with peripheral arterial disease (PAD) to see how arm exercise changes oxygen levels in their leg muscles. Participants used an arm ergometer while a sensor measured calf oxygen saturation. The goal was to understand why arm training can improve leg…
Sponsor: University of Nove de Julho • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:06 UTC
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New tool helps patients and therapists make better choices for leg pain
Knowledge-focused CompletedThis study tested a tool called KomPas+ that helps therapists and patients with leg pain from blocked arteries (intermittent claudication) make shared decisions about treatment. Over 2,200 participants used the tool to see if it improved walking distance and quality of life. The …
Phase: NA • Sponsor: Radboud University Medical Center • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:07 UTC