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Infantile spasms
MONDO:0018097A rare epilepsy syndrome characterized by onset of epileptic spasms in infants between 2 and 12 months of age, and rarely up to 24 months. Infants may have no antecedent history, or a history reflecting the underlying cause. The classical triad of epileptic spasms, hypsarrhythmia and developmental stagnation or regression is historically referred to as West syndrome.
Also known as: IESS, West syndrome, West's syndrome, infantile epileptic spasms syndrome, infantile spasms, infantile spasms syndrome, intellectual disability-hypsarrhythmia syndrome, X-linked infantile spasm syndrome
21 clinical trials for this condition and its sub-types.
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New epilepsy drug shows promise in long-term safety trial
Disease control CompletedThis study tested the long-term safety of a drug called LP352 (bexicaserin) in 41 people aged 12 to 65 with severe epilepsy syndromes like Dravet or Lennox-Gastaut. Participants took the drug three times daily for up to 52 weeks. The main goal was to check for side effects, while…
Phase: PHASE2 • Sponsor: Longboard Pharmaceuticals • Aim: Disease control
Last updated Jun 27, 2026 08:01 UTC
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Warm baths tested as seizure treatment for rare childhood disorder
Symptom relief CompletedThis study tested whether daily 20-minute warm baths could safely reduce seizures in 8 children (ages 6 months to 6 years) with CDKL5 deficiency, a rare genetic disorder causing hard-to-control seizures. The treatment was added to their usual medications for 12 weeks. The goal wa…
Phase: NA • Sponsor: Xuanwu Hospital, Beijing • Aim: Symptom relief
Last updated Jun 27, 2026 12:08 UTC
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Light-Based brain imaging may unlock secrets of infantile seizures
Knowledge-focused CompletedThis study uses a non-invasive light-based technique called near-infrared spectroscopy (NIRS) combined with EEG to measure blood flow changes in the brains of children aged 3 to 6 years during infantile epilepsy spasms. The goal is to better understand what happens in the brain b…
Sponsor: Centre Hospitalier Universitaire, Amiens • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:06 UTC
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AI spots baby seizures in home videos, could speed treatment
Knowledge-focused CompletedInfantile spasms are a type of seizure that can harm development if not treated quickly, but they are often mistaken for normal movements. This study tested a computer program that learns from parent-recorded videos to tell the difference between these seizures and harmless movem…
Sponsor: Johns Hopkins University • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:30 UTC
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Fever's impact on seizures in rare genetic disorder revealed
Knowledge-focused CompletedThis study looked at how fever changes seizure patterns in people with CDKL5 deficiency disorder, a rare genetic condition that causes hard-to-control seizures. Researchers surveyed parents of 131 affected individuals to collect information on fever history and seizure frequency.…
Sponsor: Xuanwu Hospital, Beijing • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:08 UTC