Infantile spasms
MONDO:0018097A rare epilepsy syndrome characterized by onset of epileptic spasms in infants between 2 and 12 months of age, and rarely up to 24 months. Infants may have no antecedent history, or a history reflecting the underlying cause. The classical triad of epileptic spasms, hypsarrhythmia and developmental stagnation or regression is historically referred to as West syndrome.
Also known as: IESS, West syndrome, West's syndrome, infantile epileptic spasms syndrome, infantile spasms, infantile spasms syndrome, intellectual disability-hypsarrhythmia syndrome, X-linked infantile spasm syndrome
21 clinical trials for this condition and its sub-types.
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New drug trial aims to tame seizures in rare childhood disorder
Disease control Not yet recruitingThis study tests whether the drug ganaxolone can reduce seizures in children aged 6 months to 2 years with CDKL5 deficiency disorder, a rare genetic condition causing hard-to-control seizures. Twenty children will receive either ganaxolone or a placebo alongside their usual seizu…
Phase: PHASE3 • Sponsor: Immedica Pharma AB • Aim: Disease control
Last updated Jun 27, 2026 08:00 UTC
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Hot baths tested as seizure treatment for rare childhood disorder
Symptom relief Not yet recruitingThis study tests whether taking a daily hot bath (40-42°C for 20 minutes) at home can reduce epileptic seizures in children with CDKL5 deficiency disorder. The trial will include 34 children aged 6 months to 14 years whose seizures are not controlled by medication. Researchers wi…
Phase: NA • Sponsor: Xuanwu Hospital, Beijing • Aim: Symptom relief
Last updated Jun 27, 2026 12:36 UTC
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Do brain monitors fool seizure kids? study aims to find out
Knowledge-focused Not yet recruitingThis study will check if two common brain monitors used during anesthesia (BIS and Sedline) give accurate readings in children with severe seizure disorders. Researchers will compare these monitors to a standard EEG in 40 children under 16. The goal is to make anesthesia safer fo…
Sponsor: Telethon Kids Institute • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:00 UTC