Idiopathic scoliosis

This trial tests whether scoliosis-specific exercises can stop mild spinal curves from getting worse in children and teens. Participants with mild idiopathic scoliosis will either perform daily self-corrective exercises or just follow standard observation. The study tracks how ma…

This trial compares a 3D-designed Boston brace with the standard Boston brace in 170 teens with idiopathic scoliosis, a spinal curve affecting about 3% of children. Participants wear the brace 20 hours a day until they reach skeletal maturity. Researchers measure whether the 3D b…

This study follows about 100 children with progressive idiopathic scoliosis who undergo vertebral body tethering surgery using the Tether™ device. The goal is to track safety and how well the device keeps the spine straight over time. Participants are skeletally immature with mod…

This study tests if tranexamic acid (TXA), a drug that reduces bleeding, is safe and effective for children aged 10-18 having surgery for idiopathic scoliosis. Participants are randomly assigned to one of two TXA dosing regimens or a placebo. The main goal is to measure total blo…

This study tests a new type of scoliosis brace called RESILIENT, which is flexible, adjustable, and has built-in sensors to track how long and how tightly it's worn. Researchers want to see if it can stop spinal curves from getting worse in 30 children aged 9-16 with mild to mode…

This study follows 200 scoliosis patients who have received the Ennovate Complex implant to see how safe and effective it is over time. Researchers will track changes in pain and quality of life using standard questionnaires. The goal is to confirm the device works well in real-w…

This study tests whether using a bright blue light device for 15-30 minutes each morning can slow the progression of idiopathic scoliosis in children aged 10-15 who are night owls. The trial will enroll 120 participants and follow them for 6 months, measuring spine curve changes …

This study tests whether giving vitamin A supplements to children with low vitamin A levels can slow the worsening of scoliosis (curved spine). The trial will include 140 children aged 6 to 15 who have mild to moderate scoliosis and are still growing. Half will get vitamin A plus…

This study tests whether removing the tonsils and adenoids can slow or stop the progression of scoliosis (curved spine) in children aged 6 to 15 who also have mild sleep-disordered breathing. Half of the 160 participants will have surgery within 4 weeks, while the other half will…

This study is testing the REFLECT system, a flexible implant designed to correct curved spines in children with idiopathic scoliosis while allowing natural growth. About 100 children who have failed bracing will receive the device. The main goal is to keep the spine curve at 40 d…

This study is tracking 140 children aged 5 to 17 with progressive scoliosis who receive the NEMOST V2 growing domino implant. The implant is designed to straighten the spine as the child grows. Researchers will monitor complications and how well the device works over 5 years afte…

This study is testing whether artificial intelligence can accurately diagnose spinal deformities like scoliosis by analyzing photos of a person's bare back. Researchers will enroll 2,500 participants with various spinal conditions and compare the AI's assessment to standard X-ray…

This study tests whether applying natural medicinal mud (peloidotherapy) before specialized scoliosis exercises can reduce pain and improve quality of life in young adults aged 20-40 with mild to moderate scoliosis. Researchers will compare standard exercise alone to exercise plu…

This study tests whether a methadone-based pain control plan helps children aged 10-17 recover better after spine fusion for scoliosis. About 500 teens will be randomly assigned to receive either methadone or standard opioids during and after surgery. The goal is to see if methad…

This study tests whether the drug aprepitant can prevent nausea and vomiting in children and teens after scoliosis surgery. About 100 participants aged 8 to 18 will receive either aprepitant or standard care. The goal is to see if fewer kids need extra anti-nausea medicine after …

This study tests whether taking melatonin, a natural sleep aid, can help teens aged 12-18 sleep better and recover faster after major musculoskeletal surgery (like scoliosis or hip surgery). About 45 teens will receive either a fast-dissolve melatonin pill or a placebo daily. The…

This study looks at whether adding a structured yoga program to usual care can reduce back pain and improve quality of life for teens with scoliosis. About 500 participants aged 10-20 who are not having surgery will be randomly assigned to standard care or standard care plus yoga…

This study compares two ways to manage pain after scoliosis surgery: a nerve block called MTP (injected near the spine) versus patient-controlled morphine (PCA). Forty adults with idiopathic scoliosis will be randomly assigned to one of the two methods. The main goal is to see wh…

This study tests whether a special breathing exercise device can improve lung function, exercise ability, and core strength in children and adolescents with idiopathic scoliosis who are already doing Schroth therapy. About 56 participants aged 11–16 will use the device daily for …

This pilot study uses a special MRI scan to measure water movement in the spinal discs of children aged 8 to 16, both with and without scoliosis. The goal is to learn more about how the discs behave in scoliosis, which may help explain why the condition develops. The study involv…

This study looks at adults with two types of scoliosis (idiopathic and degenerative) to understand what physical problems they have that physical therapy might help. Researchers will compare them to healthy adults using surveys and physical exams. The goal is to gather informatio…

This study is a registry that collects information from children and teens up to age 21 who are having spine surgery with robotic and navigation tools. The goal is to track how accurately screws are placed and how much radiation patients and surgeons receive. No new treatment is …

This study looks at whether teenagers with idiopathic scoliosis have trouble using visual information to stay balanced. Researchers will use motion capture to track how 70 participants (with and without scoliosis) move and maintain posture. The goal is to understand if a misunder…