Hypoparathyroidism

This Phase 3 trial tested a daily injection of TransCon PTH, a synthetic parathyroid hormone, in 84 adults with hypoparathyroidism. The goal was to see if it could help patients maintain normal blood calcium levels while reducing their need for high-dose calcium and vitamin D sup…

This phase 2 trial tested a daily injection called TransCon PTH in 59 adults with hypoparathyroidism, a condition where the body doesn't make enough parathyroid hormone. Participants were randomly assigned to receive either the drug or a placebo for four weeks, followed by an ope…

This study tested a new medicine called MBX 2109, given once a week as a shot, in 64 adults with hypoparathyroidism. The goal was to see if it could safely help patients reduce their daily calcium and vitamin D pills while keeping blood calcium levels normal. The trial was comple…

This study tested a drug called encaleret in 13 adults with post-surgical hypoparathyroidism, a condition where damaged parathyroid glands cause low blood calcium. Participants took the drug for 5 days while staying in the clinic, with frequent blood and urine tests. The goal was…

This study tested two ways of delivering synthetic parathyroid hormone (PTH) to people with chronic hypoparathyroidism, a condition where the body doesn't make enough PTH, causing low calcium. Researchers compared using an insulin pump to give steady, small doses versus twice-dai…

This study tested a new drug, palopegteriparatide, in 90 adults with chronic hypoparathyroidism. The goal was to see if the drug could help patients stop taking activated vitamin D and calcium supplements for at least four weeks. Researchers tracked how long it took to become sup…

This study tested a daily injection called TransCon PTH in 81 adults with hypoparathyroidism, a condition where the body lacks parathyroid hormone, causing low calcium levels. The goal was to see if the drug could bring calcium levels back to normal and allow patients to stop tak…

This early-stage trial tested a synthetic parathyroid hormone analog called AZP-3601 in healthy volunteers and patients with chronic hypoparathyroidism, a condition where the body doesn't produce enough parathyroid hormone. The study aimed to check safety and how the drug works i…

This study tested whether spraying a blue dye called methylene blue onto tissues during thyroid surgery helps surgeons better see and protect the nerve that controls voice and the glands that regulate calcium. 136 adults with benign thyroid nodules took part. The goal was to redu…

This study investigates whether measuring ionized calcium levels before, during, and after total thyroidectomy can predict which patients will develop low calcium levels (hypocalcemia) after surgery. Researchers will track calcium and parathyroid hormone levels in 327 adults unde…

This study is a registry that collects information from over 1,300 people with chronic hypoparathyroidism to see how well the drug rhPTH(1-84) works and how safe it is over time in everyday medical practice. Participants receive their usual care and fill out questionnaires during…

This study looked at 300 patients who had their thyroid removed to see if a parathyroid hormone (PTH) test right after surgery could predict low calcium levels. The goal was to find a threshold that rules out hypoparathyroidism. Researchers reviewed past medical records to analyz…

This early-stage study tested several new oral tablet versions of a bone-building hormone (hPTH 1-34) in 45 healthy men aged 18-35. The goal was to see how well the body absorbs these new tablets compared to an existing oral tablet and a standard daily injection. Researchers meas…

This study checked how well patients and doctors understand the risks and safe use of NATPARA, a drug for hypoparathyroidism. About 200 people took a survey online, by phone, or on paper. No medicine was given—the goal was just to measure knowledge and attitudes.

This completed study of 123 patients looked at what factors predict low calcium levels after total thyroid removal. Researchers measured calcium and parathyroid hormone (PTH) levels before and after surgery. They found that a low PTH level after surgery is a strong warning sign f…