Hypogonadotropic hypogonadism
MONDO:0018555Abnormal ovarian or testicular function due to insufficient hormonal stimulation from the hypothalamic-pituitary axis.
Also known as: Normosmic idiopathic hypogonadotropic hypogonadism, central hypogonadism, gonadotropic deficiency, hypogonadism, hypogonadotropic, hypogonadotropic hypogonadism, hypogonadotropic hypogonadism with or without anosmia, low gonadotropins (secondary hypogonadism), nIHH
100 clinical trials for this condition and its sub-types, 19 tagged with Hypogonadotropic hypogonadism itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Hypogonadotropic hypogonadism
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Congenital hypogonadotropic hypogonadism 0 trials · 83 incl. sub-types
25 sub-types
- Combined pituitary hormone deficiencies, genetic form 1 trial · 42 incl. sub-types Sub-types →
- Prader-Willi syndrome 32 trials Sub-types →
- CHARGE syndrome 4 trials Sub-types →
- Hypogonadotropic hypogonadism 7 with or without anosmia 3 trials
- Arhinia, choanal atresia, and microphthalmia 1 trial
- Isolated congenital hypogonadotropic hypogonadism 0 trials · 1 incl. sub-types Sub-types →
- Obesity due to congenital leptin deficiency 1 trial
- Obesity due to leptin receptor gene deficiency 1 trial
- Obesity due to prohormone convertase I deficiency 1 trial
- ANE syndrome 0 trials
- Kallmann syndrome-heart disease syndrome 0 trials
- Laurence-Moon syndrome 0 trials
- Martsolf syndrome 1 0 trials
- Moebius syndrome-axonal neuropathy-hypogonadotropic hypogonadism syndrome 0 trials
- Prader-Willi-like syndrome 0 trials Sub-types →
- Woodhouse-Sakati syndrome 0 trials
- X-linked adrenal hypoplasia congenita 0 trials Sub-types →
- Ataxia-hypogonadism-choroidal dystrophy syndrome 0 trials
- Brachytelephalangy-dysmorphism-Kallmann syndrome 0 trials
- Cerebellar ataxia-hypogonadism syndrome 0 trials Sub-types →
- Familial adrenal hypoplasia with absent pituitary luteinizing hormone 0 trials
- Hypogonadotropic hypogonadism-frontoparietal alopecia syndrome 0 trials
- Hypogonadotropic hypogonadism-retinitis pigmentosa syndrome 0 trials
- Hypogonadotropic hypogonadism-severe microcephaly-sensorineural hearing loss-dysmorphism syndrome 0 trials
- Polyendocrine-polyneuropathy syndrome 0 trials
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Kallmann syndrome 3 trials
18 sub-types
- Hypogonadotropic hypogonadism 1 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 11 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 14 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 15 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 16 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 17 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 18 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 19 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 2 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 20 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 21 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 22 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 3 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 4 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 5 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 6 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 8 with or without anosmia 0 trials
- Hypogonadotropic hypogonadism 9 with or without anosmia 0 trials
Most studied deeper sub-types
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Can a pill replace shots for low testosterone?
Disease control CompletedResearchers are testing an oral form of native testosterone called DITEST in men with primary or secondary hypogonadism. The trial measures how much testosterone reaches the blood after a single dose, both with and without food, and compares it to an existing oral testosterone tr…
Phase 1 • Sponsor: Neurocrine UK Limited • Aim: Disease control
Last updated Sep 16, 2026 00:00 UTC
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Could a natural hormone restore ovulation in women with hypothalamic amenorrhea?
Disease control CompletedThis early study tested whether a naturally occurring hormone called kisspeptin can stimulate reproductive hormones and help women with hypothalamic amenorrhea (a condition where periods stop due to low hormone levels) release eggs. Thirteen women received pulsatile injections of…
Phase 1 • Sponsor: Stephanie B. Seminara, MD • Aim: Disease control
Last updated Jun 27, 2026 07:53 UTC
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Could a brain hormone fix low sex hormones? small study hints at possibility
Knowledge-focused CompletedThis completed Phase 2 trial tested a natural hormone called kisspeptin in 18 adults with hypogonadotropic hypogonadism, a condition where the body doesn't produce enough sex hormones. Participants received different doses of kisspeptin to see how it affected hormone pulses. The …
Phase 2 • Sponsor: Stephanie B. Seminara, MD • Aim: Knowledge-focused
Last updated Aug 28, 2026 00:00 UTC
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Scientists hunt for genes that control puberty
Knowledge-focused CompletedThis study aims to find the genes involved in inherited reproductive disorders, such as delayed or early puberty and low hormone levels. Researchers will analyze genetic data from 600 participants with these conditions. The goal is to identify genetic variations that may explain …
Sponsor: Stephanie B. Seminara, MD • Aim: Knowledge-focused
Last updated Jul 15, 2026 00:00 UTC
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Opioid blockers may shed light on low testosterone mystery
Knowledge-focused CompletedThis study looked at how a drug that blocks opioids (naloxone) affects hormone signals in the brain related to testosterone. 23 men with a condition called hypogonadotropic hypogonadism (low testosterone) took part. The goal was to understand the body's hormone control, not to tr…
Phase 1 • Sponsor: Stephanie B. Seminara, MD • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:01 UTC
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Teen bone health under the microscope: new study looks at why some girls develop weak bones
Knowledge-focused CompletedThis completed study looked back at the medical records of 74 adolescent girls aged 12 to 21 who had bone density scans. Researchers wanted to find out which girls are most at risk for low bone density (osteopenia or osteoporosis), especially those with missed periods or other gy…
Sponsor: Bagcilar Training and Research Hospital • Aim: Knowledge-focused
Last updated Jun 26, 2026 17:13 UTC