Hypogonadism

This trial tests whether testosterone therapy can help men with spinal cord injury who have low testosterone and difficulty walking. The goal is to see if it increases muscle and bone in the legs, reduces body fat, and improves strength. Some participants also receive finasteride…

This study tests whether pelvic floor muscle training (PFMT) with a handheld biofeedback device can improve erectile function and sexual quality of life in men with functional hypogonadism (low testosterone) and erectile dysfunction. Participants are randomly assigned to PFMT wit…

This study tests whether tamoxifen, a drug commonly used for breast cancer, can speed up testosterone recovery in men with prostate cancer who have completed hormone therapy (ADT). Many men experience low testosterone for months or years after stopping ADT, causing fatigue, depre…

This study tests whether giving men with low testosterone and no sperm in their ejaculate a combination of two hormones (hCG and FSH) can help them produce usable sperm for IVF. About 860 men will either receive the hormone therapy or standard care for 16 weeks. The goal is to se…

This study tests whether testosterone implants placed under the skin can safely and effectively raise testosterone levels in men with low testosterone (hypogonadism). Thirty men will receive four implants and be monitored for six months. The goal is to see if this method provides…

This study will test whether a testosterone injection (testosterone cypionate) affects blood pressure in men with low testosterone. About 144 men will receive the injection every two weeks for 14 weeks, and their blood pressure will be monitored continuously for 24 hours. The goa…

This phase 2 trial tests a new testosterone spray (HypoSpray) in 48 men with low testosterone. Participants receive one of four doses daily for 7 days. The goal is to measure how testosterone levels change and check for skin reactions. Results will guide future, longer studies.

This study looks at whether a natural supplement called D-Chiro-inositol can help men aged 50 to 75 who have low testosterone (functional hypogonadism) and related sexual issues. Over 3 months, 35 men will take the supplement to see if their hormone levels and sexual function imp…

This study tests whether giving testosterone to frail men aged 70 and older with low testosterone can improve their strength, balance, and mental well-being, and reduce their risk of falling. About 96 men who are too weak for strength training will receive either testosterone or …

This study tests a daily testosterone gel to see if it can safely improve sexual interest and arousal in women going through menopause. Researchers will compare the gel to a placebo in 150 women aged 40-65 who have been diagnosed with low sexual desire. The goal is to provide a m…

This study looks at how anticipated stigma and illness identity affect quality of life in men with hypogonadism (low testosterone). It compares these men to those with other chronic endocrine conditions like diabetes, hypothyroidism, or hypertension. The goal is to see if these p…

This study looks at whether a testosterone lotion applied to men's skin can transfer to women through casual contact. Researchers will measure testosterone levels in the blood of female partners after skin-to-skin contact. The goal is to understand if the lotion is safe for use a…

This study looks at 40 infertile men with varicoceles (enlarged veins in the scrotum) to see if blood flow measurements in the testicles can predict how well they will respond to surgery. Participants will have ultrasound and blood tests before and three months after a standard m…