Focal epilepsy

This study tests a liquid form of the seizure drug zonisamide in children aged 1 month to 17 years who have partial-onset seizures. The goal is to find the right dose and check for side effects. About 40 children will take the medicine for up to 12 weeks, with a follow-up visit o…

This study tests a device called EASEE® that is implanted under the skin and above the skull to stimulate the brain and reduce seizures in people with drug-resistant focal epilepsy. Two hundred adults will receive the implant, and half will have the stimulation turned on for 6 mo…

This study tests a non-invasive brain training technique called neurofeedback for people with drug-resistant epilepsy. Participants learn to change their own brain activity to reduce seizures. The study compares real neurofeedback to a sham (fake) version to see if it truly works…

This study tests whether probenecid, a medicine used for gout, can stop cluster seizures in people with focal epilepsy. Participants are patients aged 6 to 50 who are in the hospital for presurgical monitoring and have their usual seizure medications paused to trigger seizures. T…

This study tests a new, more comfortable brain scanner (OPM MEG) that fits directly on the head to locate where seizures start in people with epilepsy. Researchers will compare its accuracy to standard methods in 70 patients aged 6 to 65 who are already scheduled for epilepsy sur…

This study asks whether post-traumatic stress disorder (PTSD) influences how well epilepsy surgery works. Researchers will follow 42 adults with drug-resistant focal epilepsy for two years after surgery, comparing seizure freedom and quality of life between those with and without…

This study will use brain electrodes (SEEG) and breathing monitors in 20 adults with drug-resistant epilepsy to map which brain areas control breathing during a challenge. The goal is to understand why some patients experience fatal breathing arrest after seizures (SUDEP). No tre…

This study will track 110 people with drug-resistant focal epilepsy during a hospital stay to see how often they develop mild psychotic symptoms after seizures. Researchers will use psychiatric interviews and questionnaires at three time points. The goal is to better understand t…

This study will test whether a mobile app called EPIDAY can predict the daily risk of epileptic seizures in 50 adults with focal epilepsy. Participants will use the app to report symptoms and track seizures for three months. The goal is to see if machine learning can turn these r…