Exfoliation syndrome
MONDO:0008327An autosomal dominant disorder caused by mutations in the LOXL1 gene, encoding lysyl oxidase homolog 1. The condition is characterized by abnormal fibrillar extracellular material in anterior segment tissues, and may lead to glaucoma.
Also known as: XFG, XFS, pseudoexfoliation glaucoma
40 clinical trials for this condition and its sub-types.
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Could insulin eye drops save your sight? new trial launches
Disease control Not yet recruitingThis study tests whether insulin eye drops can protect the optic nerve in people with open-angle glaucoma. Researchers will give 90 participants either insulin drops or placebo daily for up to 12 months. The main goal is to check safety, but they will also measure vision changes …
Phase: PHASE1, PHASE2 • Sponsor: Stanford University • Aim: Disease control
Last updated Jun 27, 2026 13:00 UTC
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New stitch technique aims to prevent dangerous low eye pressure after glaucoma surgery
Disease control Not yet recruitingThis study tests whether placing a temporary stitch inside a tiny drainage device (Preserflo) can reduce the risk of dangerously low eye pressure after glaucoma surgery. The device is already used in France to lower eye pressure, but low pressure can still happen. About 192 adult…
Phase: NA • Sponsor: Hôpital Privé de la Baie • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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Laser procedure could offer new hope for pseudoexfoliation glaucoma patients
Disease control Not yet recruitingThis study tests a non-invasive laser procedure called direct selective laser trabeculoplasty (DSLT) in 40 adults with pseudoexfoliation glaucoma. The goal is to see if the laser can safely lower eye pressure by at least 20% at 6 and 12 months. Participants will have their eye pr…
Phase: NA • Sponsor: Vance Thompson Vision • Aim: Disease control
Last updated Jun 27, 2026 09:03 UTC
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Eye drop showdown: could common glaucoma meds save more than sight?
Knowledge-focused Not yet recruitingThis study looks at whether a common type of glaucoma eye drop (prostaglandin analogues) can protect the eye's nerve cells directly, not just by lowering eye pressure. Researchers will review medical records from 1500 adults with glaucoma over 3 years, comparing those on prostagl…
Sponsor: Association for Innovation and Biomedical Research on Light and Image • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:29 UTC