Epidermolysis bullosa
MONDO:0006541Epidermolysis bullosa (EB) is a group of genetic skin diseases that cause the skin to blister very easily. Blisters form in response to minor injuries or friction, such as rubbing or scratching. There are four main types of epidermolysis bullosa: dystrophic epidermolysis bullosa Epidermolysis bullosa simplex Junctional epidermolysis bullosa Kindler Syndrome Identifying the exact type can be hard because there are many subtypes of EB. Within each type or subtype, a person may be mildly or severely affected. The disease can range from being a minor inconvenience to completely disabling, and fatal in some cases. Most types of EB are inherited. The inheritance pattern may be autosomal dominant or autosomal recessive. Management involves protecting the skin, reducing friction against the skin, and keeping the skin cool.
Also known as: epidermolysis bullosa, EB
44 clinical trials for this condition and its sub-types, 23 tagged with Epidermolysis bullosa itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Epidermolysis bullosa
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Inherited epidermolysis bullosa 5 trials · 37 incl. sub-types
4 sub-types
- Epidermolysis bullosa dystrophica 23 trials · 30 incl. sub-types Sub-types →
- Junctional epidermolysis bullosa 6 trials · 8 incl. sub-types Sub-types →
- Epidermolysis bullosa simplex 5 trials Sub-types →
- Kindler syndrome 0 trials Sub-types →
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Acquired epidermolysis bullosa 3 trials
Most studied deeper sub-types
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Stem cell therapy offers hope for children with butterfly skin
Disease control OngoingThis study tests a stem cell treatment for epidermolysis bullosa, a rare disease causing fragile skin that blisters easily. About 91 people with two types of EB will receive the cells or a placebo through an IV. The main goal is to see if the treatment can safely close stubborn w…
Phase 3 • Sponsor: RHEACELL GmbH & Co. KG • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Stem cell trial aims to heal wounds in 'Butterfly Skin' disease
Disease control OngoingThis phase 3 trial tests whether ABCB5-positive stem cells given through an IV can safely and effectively heal wounds in people with epidermolysis bullosa, a rare genetic condition that causes fragile, blistering skin. The study includes 9 participants with a specific type of the…
Phase 3 • Sponsor: RHEACELL GmbH & Co. KG • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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AI app aims to catch deadly skin cancer early in rare disease patients
Diagnosis OngoingThis study is developing an artificial intelligence app to detect squamous cell carcinoma (a type of skin cancer) in people with recessive dystrophic epidermolysis bullosa (RDEB), a rare genetic blistering condition. Twenty adults with RDEB and a history of skin cancer will submi…
Sponsor: Northwestern University • Aim: Diagnosis
Last updated Jun 27, 2026 09:01 UTC
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Turmeric and blue light may heal blisters in rare skin disease
Symptom relief OngoingThis study tests whether a gel made from curcumin (the active part of turmeric) combined with blue LED light can heal painful mouth blisters in people with epidermolysis bullosa, a rare condition that makes skin and mucous membranes extremely fragile. Twenty participants will rec…
Phase 4 • Sponsor: Universidade Ceuma • Aim: Symptom relief
Last updated Jul 18, 2026 00:00 UTC
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Bubble bath breakthrough? new study tests microbubble therapy for tough skin diseases
Symptom relief By invitation onlyThis early study will test a special microbubble bath system (Thera-Clean) on 20 people with certain skin diseases like epidermolysis bullosa, ichthyosis, atopic dermatitis, or psoriasis. The goal is to see if the chemical-free bubbles can clean wounds, reduce itching, and improv…
Early phase 1 • Sponsor: Northwestern University • Aim: Symptom relief
Last updated Jun 27, 2026 09:02 UTC
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New eye drops aim to soothe blistering eye pain in rare skin disease
Symptom relief OngoingThis early-stage study tests whether ELK-003 eye drops can safely reduce eye symptoms in people with two types of epidermolysis bullosa (EB), a rare condition causing fragile skin and blisters. About 20 participants will first be observed without treatment, then receive the eye d…
Phase 1 • Sponsor: Fundación DEBRA Chile, Niños Piel de Cristal • Aim: Symptom relief
Last updated Jun 27, 2026 08:07 UTC