Enuresis

This trial tests whether limiting digital-device use for at least an hour before bed can improve the response to desmopressin, a medication that reduces nighttime urine production, in children aged 6 to 14 with primary monosymptomatic nocturnal enuresis (bedwetting). Participants…

This trial tests a device called Adjustable Continence Therapy (ACT) for women with stress urinary incontinence caused by a weak urethral sphincter. The implant has two balloons placed near the bladder neck that can be adjusted after surgery to improve control. The study will enr…

This study tests whether a caregiver-led telehealth program can help autistic children ages 5 to 12 who still have bowel accidents after completing treatment for bedwetting. About 150 children will take part. The program teaches caregivers strategies to manage encopresis, with th…

This study looks at whether a combination of two drugs (solifenacin and mirabegron) at low doses works better than a high dose of either drug alone for children aged 5 to 14 with daytime wetting. About 236 children who did not fully respond to low-dose single drugs will be random…

This study tests whether injecting botulinum toxin-A (like Botox) into the bladder can help children with certain bladder problems that haven't improved with standard treatments. It includes children under 18 with either dysfunctional voiding (trouble peeing normally) or nighttim…

This early study tests a device called UCon, which is placed on the skin to send mild electrical pulses to nerves that control the bladder and bowel. The goal is to reduce symptoms like sudden urges, leaks, and frequent bathroom trips in women with overactive bladder or bowel dys…

This early study tests a device called UCon that sends mild electrical pulses through the skin to calm bladder nerves. Twenty men with overactive bladder will use the device at home for a few weeks. The goal is to see if it is safe and if it reduces urgency, leaks, and nighttime …

This study tests whether a combination of two drugs (mirabegron and solifenacin) works better than the standard drug (desmopressin) for children who wet the bed. About 120 children will take one of the treatments daily for 3 months. The goal is to see which approach reduces the n…

This study looks at whether using a TENS machine (a device that sends mild electrical pulses through the skin) can reduce bedwetting in children. 70 kids who have not improved with simple behavior changes will use the device on their ankle for 30 minutes each night for a month. R…

This study looks at brain activity in children with overactive bladder and daytime wetting compared to healthy children. Researchers use MRI scans to see if brain areas that control the bladder work differently. They also test if a gentle nerve stimulation treatment (TENS) change…

This study looks at how blood clots form and break down in women after surgery for uterine prolapse or urine incontinence. Researchers will measure clot properties and thrombin generation in 60 women aged 18-70 who did not improve with medication. The goal is to better understand…