Enamel caries

This pilot trial tests a gel called Epinamel that aims to regrow tooth enamel naturally by using minerals from saliva. It includes 20 people who just had their braces removed and have white spot lesions—early signs of decay—on both sides of their mouth. The gel is applied to one …

This trial tests whether a varnish made from nano-sized eggshell can help reverse the earliest stage of tooth decay (enamel caries) in adolescents aged 15-20. It compares the eggshell varnish against two established treatments: a CPP-ACP paste (GC Tooth Mousse) and a standard 5% …

This trial compares two treatments for white spot lesions—early cavities that appear as milky-white marks on front teeth after braces. One treatment uses a special paste (MI Paste Plus) combined with etching, while the other uses a resin infiltration technique (Icon). The study i…

This study tests whether ozone therapy, followed by a remineralizing gel, can reverse the earliest stage of cavities in children aged 6-14. Half of the 80 participants will get ozone plus gel, the other half just gel. Researchers will check the teeth over 8 weeks using special li…

This study tests whether a self-assembling peptide called P11-4 can help remineralize white spot lesions—early signs of tooth decay—on smooth tooth surfaces. Seventy-five participants aged 10 to 17 will be split into three groups: one gets a single peptide application, another ge…

This study tests a new cleaning method (air-polishing with erythritol) against standard cleaning (ultrasound) to prevent white spots on teeth and gum inflammation in 60 teens aged 12-16 who are getting braces. Participants will be followed for 2 years to see which method works be…

This study tests whether a daily cream called MI Paste Plus can reduce cavity-causing bacteria and prevent white spots on teeth in people with braces. Two hundred participants will apply the cream nightly for three months. Researchers will measure bacteria levels and check for ne…

This study tests two kinds of toothpaste that contain hydroxyapatite, a mineral that helps rebuild tooth enamel. Forty children and teens with early signs of enamel damage will brush with one of the pastes twice a day for six months. Researchers will measure if the enamel gets st…

This study tests whether a fluorescent starch nano-particle mouth rinse, combined with saliva biomarkers, can detect the earliest stages of tooth decay more accurately than a traditional visual exam. Sixty adults with at least one suspected early enamel lesion will be evaluated u…

This study looks at whether a toothpaste or mouthwash containing hydroxyapatite can prevent white spot lesions (early cavities) that often appear during orthodontic treatment with braces. 75 people getting braces will be split into three groups: one using hydroxyapatite toothpast…

This study tests three cavity-prevention methods in 204 Mexican schoolchildren aged 6-8. One group gets fluoride varnish alone, another gets a glass ionomer sealant plus fluoride varnish, and the third gets a Giomer® sealant. All children also receive dental health education. Res…

This study tests a new adhesive for braces that doesn't require acid etching, which can weaken enamel and cause white spots. Twenty people getting braces will have one side of their mouth bonded with the new glue and the other side with the standard method. Researchers will track…

This study surveys 100 dental professionals to find the best methods for cleaning teeth after braces are removed, aiming to reduce enamel damage and tooth sensitivity. It compares different tools and techniques used in clinics. The goal is to identify the safest, most effective a…