Dysostosis

This trial tests whether a daily routine of tummy time and careful positioning can help correct cranial asymmetry—a flattened head shape—in premature newborns. About 300 babies born before 37 weeks who are in the neonatal ICU or intermediate care unit will be split into two group…

This early-stage study aims to develop a personalized treatment for children with syndromic craniosynostosis, a group of rare genetic disorders where skull bones fuse too early. The approach uses a nano-engineered gel to deliver custom genetic medicine directly to the affected ar…

This study tests a surgical procedure to correct a rare condition where the two bones in the forearm are fused together, limiting rotation. The surgery involves cutting and repositioning the bones, then using Kirschner wires to hold them in place. The study will enroll one child …

This study looks at skull bone samples from 80 infants aged 3 to 12 months who have craniosynostosis, a condition where skull bones fuse too early. Researchers will measure the bone's strength, structure, and tissue makeup both near and far from the fused area. The goal is to bet…

This study looks at medical records and parent questionnaires from about 28 children with a rare hand condition called longitudinal ulnar deficiency. The goal is to better understand how the condition changes over time and what factors lead to surgery. No new treatments or tests …

This study will follow 270 children with severe positional head deformity who are already using a cranial helmet. Researchers will measure head shape changes, neck rotation, and body surface temperature using thermal imaging. The goal is to understand how helmet therapy might inf…