Disorder of sexual differentiation

This phase 3 study tests a new weekly growth hormone injection (inpegsomatropin) against an existing one (givopegsomatropin) in 84 girls with Turner syndrome who have short stature. The goal is to see which works better for increasing growth over 52 weeks. Participants are prepub…

This trial tests two ways of giving estrogen to girls and young women with Turner syndrome to help them start puberty. Participants will be randomly assigned to use either an estrogen gel applied to the skin or an estrogen tablet taken by mouth for 19 months. The study will compa…

This study tests whether a 40-minute hands-on breastfeeding class during the third trimester can prevent sore nipples and breast engorgement in first-time mothers. 100 pregnant women will be split into two groups: one gets the class plus an e-booklet, the other gets only the e-bo…

This study tests a new robotic surgery to remove excess breast gland tissue in men with gynecomastia (enlarged breasts). Twenty men aged 18-75 who have had breast enlargement for over a year and haven't responded to medication will undergo single-port robotic-assisted surgery. Th…

This study will compare different surgical techniques for treating severe gynecomastia (enlarged male breasts) in 45 men aged 18-60. The goal is to see which method gives the best cosmetic results and highest patient satisfaction. Participants will be randomly assigned to one of …

Denys-Drash syndrome is a rare genetic condition that causes kidney failure in early childhood, often requiring a transplant. Past research suggests these children have a much higher chance of developing a type of lymphoma after transplant compared to other kids. This study will …