Digestive system cancer
MONDO:0002516A primary or metastatic malignant neoplasm involving any part of the digestive system.
Also known as: GI tumor, GI tumour, cancer of digestive system, digestive system cancer, gastrointestinal system cancer, malignant digestive system neoplasm, malignant gastrointestinal neoplasm, malignant gastrointestinal system neoplasm
9498 clinical trials for this condition and its sub-types, 267 tagged with Digestive system cancer itself.
Follow this condition to get notified about new trialsWhere it sits in the disease tree
Browse by category →Sub-types of Digestive system cancer
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Digestive system carcinoma 25 trials · 4,898 incl. sub-types
16 sub-types
- Carcinoma of liver and intrahepatic biliary tract 36 trials · 1,461 incl. sub-types Sub-types →
- Colorectal carcinoma 305 trials · 1,170 incl. sub-types Sub-types →
- Exocrine pancreatic carcinoma 205 trials · 1,037 incl. sub-types Sub-types →
- Gastric carcinoma 92 trials · 555 incl. sub-types Sub-types →
- Carcinoma of esophagus 76 trials · 509 incl. sub-types Sub-types →
- Gastroesophageal junction adenocarcinoma 507 trials
- Carcinoma of pharynx 3 trials · 457 incl. sub-types Sub-types →
- Oral cavity carcinoma 16 trials · 202 incl. sub-types Sub-types →
- Small intestine carcinoma 19 trials · 105 incl. sub-types Sub-types →
- Gallbladder carcinoma 41 trials · 49 incl. sub-types Sub-types →
- Intestine carcinoma in situ 0 trials · 16 incl. sub-types Sub-types →
- Pancreatic endocrine carcinoma 12 trials Sub-types →
- Digestive system mixed adenoneuroendocrine carcinoma 0 trials · 3 incl. sub-types Sub-types →
- Carcinoma of floor of mouth 1 trial · 2 incl. sub-types Sub-types →
- Maxillary sinus carcinoma 1 trial · 2 incl. sub-types Sub-types →
- Ameloblastic carcinoma 0 trials
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Intestinal cancer 25 trials · 2,791 incl. sub-types
6 sub-types
- Colorectal cancer 1,770 trials · 2,702 incl. sub-types Sub-types →
- Small intestine cancer 8 trials · 118 incl. sub-types Sub-types →
- Anal canal cancer 22 trials · 44 incl. sub-types Sub-types →
- Intestine carcinoma in situ 0 trials · 16 incl. sub-types Sub-types →
- Colorectal Kaposi sarcoma 0 trials Sub-types →
- Gastric intestinal type adenocarcinoma 0 trials
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Liver cancer 255 trials · 1,708 incl. sub-types
5 sub-types
- Carcinoma of liver and intrahepatic biliary tract 36 trials · 1,461 incl. sub-types Sub-types →
- Biliary tract cancer 244 trials · 618 incl. sub-types Sub-types →
- Liver sarcoma 1 trial · 10 incl. sub-types Sub-types →
- Liver lymphoma 1 trial Sub-types →
- Calcifying nested epithelial stromal tumor of the liver 0 trials
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Malignant pancreatic neoplasm 903 trials · 1,450 incl. sub-types
4 sub-types
- Malignant exocrine pancreas neoplasm 4 trials · 1,057 incl. sub-types Sub-types →
- Pancreatic endocrine carcinoma 12 trials Sub-types →
- Pancreas lymphoma 0 trials Sub-types →
- Pancreas sarcoma 0 trials
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Gastric cancer 724 trials · 1,035 incl. sub-types
9 sub-types
- Gastric carcinoma 92 trials · 555 incl. sub-types Sub-types →
- Cardia cancer 0 trials · 7 incl. sub-types Sub-types →
- Diffuse gastric cancer 3 trials
- Gastric lymphoma 1 trial · 3 incl. sub-types Sub-types →
- Gastric leiomyosarcoma 0 trials
- Gastric liposarcoma 0 trials
- Malignant gastric germ cell tumor 0 trials Sub-types →
- Malignant gastric granular cell tumor 0 trials
- Pylorus cancer 0 trials Sub-types →
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Esophageal cancer 408 trials · 791 incl. sub-types
7 sub-types
- Carcinoma of esophagus 76 trials · 509 incl. sub-types Sub-types →
- Malignant neoplasm of thoracic esophagus 3 trials
- Esophageal melanoma 1 trial
- Malignant neoplasm of cervical esophagus 1 trial
- Esophagus lymphoma 0 trials
- Esophagus sarcoma 0 trials Sub-types →
- Malignant neoplasm of abdominal esophagus 0 trials
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Pharynx cancer 10 trials · 497 incl. sub-types
5 sub-types
- Oropharynx cancer 150 trials · 280 incl. sub-types Sub-types →
- Malignant tumor of nasopharynx 9 trials · 214 incl. sub-types Sub-types →
- Pharyngeal squamous cell carcinoma 5 trials · 203 incl. sub-types Sub-types →
- Hypopharynx cancer 50 trials · 100 incl. sub-types Sub-types →
- Pharyngeal adenoid cystic carcinoma 0 trials
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Oral cavity cancer 42 trials · 290 incl. sub-types
11 sub-types
- Oral cavity carcinoma 16 trials · 202 incl. sub-types Sub-types →
- Salivary gland cancer 62 trials · 81 incl. sub-types Sub-types →
- Tongue cancer 26 trials · 35 incl. sub-types Sub-types →
- Lip cancer 12 trials · 15 incl. sub-types Sub-types →
- Cheek mucosa cancer 1 trial · 2 incl. sub-types Sub-types →
- Gingival cancer 1 trial · 2 incl. sub-types Sub-types →
- Hard palate cancer 0 trials · 1 incl. sub-types Sub-types →
- Retromolar area cancer 1 trial
- Soft palate cancer 0 trials · 1 incl. sub-types Sub-types →
- Oral rhabdomyosarcoma 0 trials
- Vestibule of mouth cancer 0 trials Sub-types →
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Gastroesophageal cancer 157 trials
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Gallbladder cancer 75 trials · 109 incl. sub-types
5 sub-types
- Gallbladder carcinoma 41 trials · 49 incl. sub-types Sub-types →
- Gallbladder melanoma 1 trial
- Gallbladder lymphoma 0 trials
- Gallbladder sarcoma 0 trials Sub-types →
- Neurofibroma of gallbladder 0 trials
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Gastrointestinal lymphoma 0 trials · 7 incl. sub-types
10 sub-types
- Gastric lymphoma 1 trial · 3 incl. sub-types Sub-types →
- Small intestine lymphoma 3 trials Sub-types →
- Liver lymphoma 1 trial Sub-types →
- Colorectal lymphoma 0 trials Sub-types →
- Esophagus lymphoma 0 trials
- Gallbladder lymphoma 0 trials
- Pancreas lymphoma 0 trials Sub-types →
- Splenic manifestation of hairy cell leukemia 0 trials
- Splenic manifestation of prolymphocytic leukemia 0 trials
- Tonsillar lymphoma 0 trials
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Jaw cancer 1 trial · 5 incl. sub-types
3 sub-types
- Maxillary sinus carcinoma 1 trial · 2 incl. sub-types Sub-types →
- Mandibular cancer 1 trial
- Retromolar area cancer 1 trial
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Digestive system melanoma 0 trials · 2 incl. sub-types
3 sub-types
- Rectum malignant melanoma 1 trial · 2 incl. sub-types Sub-types →
- Esophageal melanoma 1 trial
- Gallbladder melanoma 1 trial
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Malignant tumor of floor of mouth 0 trials · 2 incl. sub-types
1 sub-type
- Carcinoma of floor of mouth 1 trial · 2 incl. sub-types Sub-types →
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Spleen cancer 0 trials · 2 incl. sub-types
5 sub-types
- Gastric mucosa-associated lymphoid tissue lymphoma 2 trials
- Small intestinal mucosa-associated lymphoid tissue lymphoma 0 trials
- Spleen angiosarcoma 0 trials
- Splenic manifestation of leukemia 0 trials Sub-types →
- Tonsillar lymphoma 0 trials
Most studied deeper sub-types
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New drug combo shows early promise against Hard-to-Treat cancers
Disease control Stopped earlyThis early-stage study tested a new drug called BI 765049, alone or combined with another drug (ezabenlimab), in 21 Asian adults with advanced solid tumors (stomach, colorectal, pancreatic, liver, head and neck, or lung cancer) that have a specific marker called B7-H6. The main g…
Phase 1 • Sponsor: Boehringer Ingelheim • Aim: Disease control
Last updated Aug 29, 2026 00:00 UTC
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Quitting before the knife: which Stop-Smoking aid works best for cancer patients?
Disease control Stopped earlyThis trial explores whether adding counseling, cognitive behavioural therapy, or hypnotherapy to nicotine replacement therapy can help cancer patients quit smoking before their surgery. The study includes adults with breast, digestive, gynecologic cancer, or melanoma who smoke da…
Sponsor: Institut Cancerologie de l'Ouest • Aim: Disease control
Last updated Aug 09, 2026 00:00 UTC
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Brain cancer trial halted early: can Memory-Sparing radiation help when tumors return?
Disease control Stopped earlyThis phase III trial compared two radiation strategies for cancer that had spread to the brain and returned in new spots after initial radiosurgery. One group received focused radiation only to the new tumors, while the other received whole brain radiation that avoided the memory…
Phase 3 • Sponsor: NRG Oncology • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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Experimental cell therapy targets tough cancers, but trial ends early
Disease control Stopped earlyThis early-phase trial tested a new approach: taking a patient's own white blood cells, genetically modifying them in the lab to recognize a specific cancer mutation (KRAS G12D), and infusing them back to attack tumors. The study enrolled only 5 adults with advanced gastrointesti…
Phase 1/2 • Sponsor: National Cancer Institute (NCI) • Aim: Disease control
Last updated Jun 27, 2026 12:35 UTC
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Cancer combo trial halted early: what we learned
Disease control Stopped earlyThis study tested a combination of two drugs, donafenib and KN046, in people with advanced gastrointestinal cancers that had not responded to standard treatments. The goal was to check safety and see if the drugs could shrink tumors. The trial was stopped early, and only 15 peopl…
Phase 1/2 • Sponsor: Suzhou Zelgen Biopharmaceuticals Co.,Ltd • Aim: Disease control
Last updated Jun 27, 2026 12:28 UTC
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New blood thinner tested for cancer Patients' clots – study halted early
Disease control Stopped earlyThis phase 3 trial tested a new drug, abelacimab, against a standard blood thinner (dalteparin) to prevent dangerous blood clots from returning in people with gastrointestinal or genitourinary cancers. The study enrolled 417 adults with advanced cancer and a recent clot. It was t…
Phase 3 • Sponsor: Anthos Therapeutics, Inc. • Aim: Disease control
Last updated Jun 27, 2026 12:08 UTC
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New antibody drug tested in patients with advanced stomach and gut cancers
Disease control Stopped earlyThis early-stage study tested a new drug called DR30303 in 13 people with advanced digestive system cancers that had stopped responding to standard treatments. The drug is a lab-made antibody designed to target a protein called CLDN18.2 found on some cancer cells. The main goals …
Phase 1 • Sponsor: Zhejiang Doer Biologics Co., Ltd. • Aim: Disease control
Last updated Jun 27, 2026 12:06 UTC
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Quit smoking before surgery to cut complications, study finds
Disease control Stopped earlyThis study looked at whether a structured smoking cessation program starting four weeks before surgery could reduce complications in smokers undergoing intermediate to high-risk operations. Researchers planned to enroll 251 adult smokers scheduled for surgeries like abdominal, th…
Sponsor: Luzerner Kantonsspital • Aim: Disease control
Last updated Jun 27, 2026 09:09 UTC
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Engineered immune cells take on Hard-to-Treat gut cancers
Disease control Stopped earlyThis early-phase study tested a new treatment called LCAR-G08, which uses a patient's own immune cells (T-cells) that are modified in a lab to recognize and attack cancer cells in the gut. The study included 17 adults with advanced colorectal, stomach, pancreatic, or small bowel …
Phase 1 • Sponsor: Peking University • Aim: Disease control
Last updated Jun 27, 2026 09:02 UTC
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Short nutrition boost before cancer surgery: does it help?
Disease control Stopped earlyThis study looked at whether giving well-nourished people with gastrointestinal cancer a special nutrition drink for 3 days before surgery could reduce complications and shorten hospital stays. The trial was stopped early, so results are limited. It involved 107 adults with stoma…
Sponsor: Société des Produits Nestlé (SPN) • Aim: Disease control
Last updated Jun 27, 2026 08:03 UTC
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Cancer combo trial halted early: what we know
Disease control Stopped earlyThis phase 2 trial tested two drugs—ulixertinib and hydroxychloroquine—in 47 people with advanced gastrointestinal cancers that have certain genetic mutations (MAPK pathway). The goal was to see if the combination could shrink tumors. However, the study was terminated early, so t…
Phase 2 • Sponsor: BioMed Valley Discoveries, Inc • Aim: Disease control
Last updated Jun 27, 2026 07:51 UTC
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New drug combo tested for Hard-to-Treat cancers
Disease control Stopped earlyThis early-phase trial tested an experimental drug called INCA00186, alone or with other immunotherapy drugs, in people with advanced solid tumors such as head and neck or gastrointestinal cancers. The study aimed to find safe doses and check for early signs of effectiveness. It …
Phase 1 • Sponsor: Incyte Corporation • Aim: Disease control
Last updated Jun 26, 2026 12:43 UTC
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Fat Tissue's hidden powerhouse: location may shape metabolism
Knowledge-focused Stopped earlyThis study investigates how the location of fat tissue in the body—under the skin versus around the organs—affects the function of mitochondria, the energy-producing parts of cells. Researchers will collect small samples of fat tissue from patients undergoing certain abdominal su…
Sponsor: University Hospital, Clermont-Ferrand • Aim: Knowledge-focused
Last updated Aug 09, 2026 00:00 UTC