Congenital temporomandibular joint ankylosis
MONDO:0016220Congenital temporomandibular joint ankylosis is a rare maxillofacial disorder characterized by significant reduction in mouth opening (i.e. from a few millimeters to a few centimeters) in the absence of acquired factors (e.g. trauma, infection) contributing to the ankylosis. It is associated with variable degrees of facial dysmorphism (i.e. lateral deviation of the mandible and chin, lower facial asymmetry, retrognathia, micrognathia, dental malocclusion) and patients typically present with feeding and breathing difficulties. Developmental delay, hypotonia, seizures, and additional dysmorphic features (e.g. pectus excavatum, low-set ears, hypoplastic alae nasi) have also been reported.
Also known as: congenital trismus
27 clinical trials for this condition and its sub-types.
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Virtual jaw simulator could spot hidden joint problems
Diagnosis Not yet recruitingThis study will test a 4D virtual simulator called Modjaw to see if it helps doctors diagnose temporomandibular joint (TMJ) disorders more accurately. About 20 adults with suspected disc displacement will use the device, and the results will be compared to MRI scans. The goal is …
Phase: NA • Sponsor: Centre Hospitalier Universitaire de Nice • Aim: Diagnosis
Last updated Jun 27, 2026 12:01 UTC
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Can a hybrid 3D-Printed splint ease jaw pain better than traditional ones?
Symptom relief Not yet recruitingThis trial tests whether a new type of dental splint—made with both hard and soft 3D-printed materials—can improve comfort and outcomes for people with temporomandibular joint (TMJ) disorders. It compares the hybrid splint to conventional chairside splints and standard 3D-printed…
Phase: NA • Sponsor: Postgraduate Institute of Dental Sciences Rohtak • Aim: Symptom relief
Last updated Aug 14, 2026 00:00 UTC
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Could a simple pill boost knee replacement recovery?
Symptom relief Not yet recruitingThis study tests whether taking tranexamic acid pills for a week after knee replacement surgery helps people recover better. 350 adults having their first knee replacement will receive either the drug or a placebo. Researchers will track pain, stiffness, and function for up to 2 …
Phase: NA • Sponsor: NYU Langone Health • Aim: Symptom relief
Last updated Jun 27, 2026 12:00 UTC
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Can a new italian questionnaire unlock the fear behind jaw pain?
Knowledge-focused Not yet recruitingThis study is translating and testing an Italian version of a questionnaire that measures kinesiophobia—the fear of movement—in people with temporomandibular disorders (TMDs), which affect the jaw joint and muscles. Researchers will ask 250 adults diagnosed with TMD to complete t…
Sponsor: Alessandro Aquino • Aim: Knowledge-focused
Last updated Aug 09, 2026 00:00 UTC
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Jaw misalignment linked to posture? 3D spine scans investigate
Knowledge-focused Not yet recruitingThis study looks at whether the way your jaw and teeth fit together (called malocclusion) is related to your body posture. Researchers will use a 3D scanner to measure the spine's curves and alignment in people with different types of jaw misalignment. The goal is to better under…
Sponsor: Andrea Scribante • Aim: Knowledge-focused
Last updated Jun 27, 2026 14:02 UTC
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Blood injections after jaw surgery: which works better?
Knowledge-focused Not yet recruitingThis study looks at 700 adults who had jaw joint (TMJ) surgery and received either platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) injections during the operation. Researchers will review medical records to see which group had less pain and better jaw function six months…
Sponsor: Jingping Wang, MD, Ph.D. • Aim: Knowledge-focused
Last updated Jun 27, 2026 13:05 UTC
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New study eyes Tirzepatide's hidden impact on joints and heart
Knowledge-focused Not yet recruitingThis observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…
Sponsor: JULIO GRANADOS MONTIEL • Aim: Knowledge-focused
Last updated Jun 27, 2026 12:31 UTC
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Can a simple hand technique improve jaw movement? new study investigates
Knowledge-focused Not yet recruitingThis study looks at how the position of your head affects the movement of your jaw joints (TMJ) in people aged 11 to 65 who are getting braces or dental reconstruction. Researchers will measure jaw and neck movement before and after a brief hands-on therapy session to see if it h…
Phase: NA • Sponsor: The Jerzy Kukuczka Academy of Physical Education in Katowice • Aim: Knowledge-focused
Last updated Jun 27, 2026 08:06 UTC