Complex regional pain syndrome
MONDO:0019369A chronic pain syndrome characterized by a disproportionate spontaneous or stimulus-induced pain, accompanied by a variably mixed myriad of autonomic and motor disorders including symptoms such as swelling, allodynia, skin blood supply and trophic disturbances. CRPS most often affects one of the arms, legs, hands, or feet and usually occurs after an injury or trauma to that limb.
Also known as: CRPS, algoneurodystrophy, reflex sympathetic dystrophy
197 clinical trials for this condition and its sub-types, 65 tagged with Complex regional pain syndrome itself.
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Sub-types of Complex regional pain syndrome
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Complex regional pain syndrome type 1 31 trials
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Complex regional pain syndrome type 2 18 trials
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Can mental imagery rewire the Brain's map of a painful limb?
Symptom relief Not yet recruitingComplex regional pain syndrome (CRPS) causes severe, lasting pain and can distort how people perceive the affected body part. Researchers are testing whether graded motor imagery, a rehabilitation approach that uses mental exercises and mirror therapy, can improve body perception…
Sponsor: Nantes University Hospital • Aim: Symptom relief
Last updated Sep 16, 2026 00:00 UTC
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One two-hour class could ease the burden on parents of kids in pain
Symptom relief Not yet recruitingThis study tests a new program called Empowered Relief for Caregivers (ER-CY), a single two-hour online class for caregivers of children and teens with chronic pain. Up to 80 caregivers will take the class and complete surveys and interviews over three months. The goal is to see …
Sponsor: Stanford University • Aim: Symptom relief
Last updated Aug 22, 2026 00:00 UTC
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Rewiring the brain to silence chronic pain — a bold psychological therapy is put to the test
Symptom relief Not yet recruitingThis trial tests whether pain reprocessing therapy (PRT) — a brief psychological treatment that combines education, cognitive restructuring, and body-focused techniques — can reduce chronic pain. Adults with persistent pain lasting over three months are randomly assigned to full …
Sponsor: Ben-Gurion University of the Negev • Aim: Symptom relief
Last updated Jul 26, 2026 00:00 UTC
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Could a Nerve-Zapping ear device ease chronic pain?
Symptom relief Not yet recruitingThis study tests whether adding a gentle electrical stimulation to the ear — targeting the vagus nerve — can improve pain and function in adults with complex regional pain syndrome type I (CRPS-I) affecting the hand or arm. All participants receive standard rehabilitation, but ha…
Sponsor: Liv Hospital Vadistanbul • Aim: Symptom relief
Last updated Jul 19, 2026 00:00 UTC
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Could gabapentin or oxcarbazepine ease chronic nerve pain in kids?
Symptom relief Not yet recruitingThis study compares two drugs, gabapentin and oxcarbazepine, for treating chronic nerve pain in children aged 8 to 18. Sixty participants will receive one drug or the other in a blinded fashion, with the option to switch if pain doesn't improve. The goal is to see which drug redu…
Phase 3 • Sponsor: Boston Children's Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 09:10 UTC
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Can a bone Drug's pain relief last? registry tracks CRPS-1 patients after neridronate
Knowledge-focused Not yet recruitingThis observational registry follows people with complex regional pain syndrome type 1 (CRPS-1) who received neridronate infusions in a separate clinical trial. For 12 to 24 months, participants answer online surveys about their pain, sleep, medication use, procedures, and daily f…
Sponsor: Ambros Therapeutics, Inc. • Aim: Knowledge-focused
Last updated Sep 12, 2026 00:00 UTC