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Can mental imagery rewire the Brain's map of a painful limb?

NCT ID NCT07818174

Symptom relief Sponsor: Nantes University Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting This study
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 14, 2026 · Last updated Sep 15, 2026 · Updated 1 time

Summary

Complex regional pain syndrome (CRPS) causes severe, lasting pain and can distort how people perceive the affected body part. Researchers are testing whether graded motor imagery, a rehabilitation approach that uses mental exercises and mirror therapy, can improve body perception in adults with upper limb CRPS. The trial compares six weeks of graded motor imagery plus standard exercises against sham mental imagery plus standard exercises in 80 participants. Physiotherapists deliver the sessions, and assessors who do not know which treatment each person received measure the results.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
graded motor imagery, a rehabilitation technique using mental imagery and mirror therapy
What this could lead to
If it works, graded motor imagery could become a standard part of rehabilitation for people with complex regional pain syndrome, helping them feel more connected to the affected limb.
What could go wrong
This is a small, single-country trial of 80 people, so results may not apply broadly. Graded motor imagery requires daily practice and may not help everyone, and some participants may find the mental imagery exercises difficult or uncomfortable.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Jul 2028

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Over 18 years * Upper limb unilateral CRPS (Budapest criteria) * No prior use of GMI Exclusion Criteria: * Psychiatric disorders * Not confident with written/spoken French * Not confident with smartphone use

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Conditions

The condition(s) this trial relates to.

Chronic Pain complex regional pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Complex regional pain syndromes

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    20 sites. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Cabinet de kinésithérapie AMBON 56190 3b route de Lauzach

    Ambon, 56190, France

  • Cabinet de kinésithérapie du Mail Pablo Picasso, 5 Rue Nina Simone,

    Nantes, 44000, France

  • Cabinet de kinésithérapie, 20220 L'ILE ROUSSE 8 Bd Pasquini

    L'Île-Rousse, 20220, France

  • Cabinet de kinésithérapie, 34000 Montpellier, 22, avenue du Pont Juvénal

    Montpellier, 34000, France

  • Cabinet de kinésithérapie, 44100 NANTES 7 RUE DU SIMOUN

    Nantes, 44100, France

  • Cabinet de kinésithérapie, 44400 REZE 15 avenue Louise Michel

    Rezé, 44400, France

  • Cabinet de kinésithérapie, 45100 Orléans 44 avenue de la Mouillère

    Orléans, 45100, France

  • Cabinet de kinésithérapie, 56520 6 place Louis le Montagner

    Guidel, 56520, France

  • Cabinet de kinésithérapie, 64121 Serres Castet 7 bis chemin de Liben

    Serres-Castet, 64121, France

  • Cabinet de kinésithérapie, 69008 LYON 16 rue du transvaal

    Lyon, 69008, France

  • Cabinet de kinésithérapie, 85610 CUGAND 19bis rue du président auguste durand

    Cugand, 85610, France

  • Cabinet de kinésithérapie, CAEN 14000 41 av. père Charles de Foucauld

    Caen, 14000, France

  • Cabinet de kinésithérapie, ERAGNY 95610 5 allée Rosa Luxemburg

    Éragny, 95610, France

  • Cabinet de kinésithérapie, ERAGNY 95610 5 allée Rosa Luxemburg

    Éragny, 95610, France

  • Cabinet de kinésithérapie, PARIS 75019 2, rue de Sadi Lecointe

    Paris, 75019, France

  • cabinet de kinésithérapie, 03270 SAINTYORRE 10, rue de la République

    Saint-Yorre, 03270, France

  • cabinet de kinésithérapie, 44100 NANTES 8ter rue de la convention

    Nantes, 44100, France

  • cabinet de kinésithérapie, 44800 St Herblain Boulevard charles gautier

    Saint-Herblain, 44800, France

  • cabinet de kinésithérapie, 64121 Serres Castet 7 bis chemin de Liben

    Serres-Castet, 64121, France

  • cabinet de kinésithérapie, NANTES 44100 2-4 route de Paris

    Nantes, 44100, France

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