Colorectal adenoma

This study tests a vaccine that helps the body's immune system recognize and attack advanced colon polyps, which can turn into cancer. About 110 people who have had these polyps removed will receive either the vaccine or a placebo. The goal is to see if the vaccine boosts immune …

This study is testing a robotic device that doctors use through the anus to remove benign growths (polyps, adenomas) from the rectum and sigmoid colon. The goal is to see if the device can remove the entire growth in one piece safely, without causing bleeding or a hole in the bow…

This Phase 2 trial is testing whether linaclotide, a drug currently used for constipation, can slow or prevent colorectal cancer growth. About 150 people with colorectal polyps or early-stage cancer will take the drug or a placebo before surgery. Researchers will measure changes …

This study tests a computer program that analyzes colonoscopy images to help doctors decide if a growth (polyp) is an adenoma (pre-cancerous) or not. The software gives a probability score for each lesion. The trial involves 1,178 adults and compares the software's results to lab…

This study aims to see how well a new stool test, called LifeKit Prevent, can detect colorectal cancer and precancerous growths (adenomas). About 12,000 adults aged 40 and older scheduled for a screening colonoscopy will provide a stool sample for the test. The results will be co…

This study tests whether a high-fiber diet centered on legumes like dry beans can help overweight or obese adults who have had colon polyps lose weight and reduce their risk of colon cancer. Participants follow a diet with pre-portioned meals for up to a year, with nutritionist s…

This study looks at whether taking aspirin in different patterns can help prevent colorectal cancer in people who have had colon polyps (adenomas). Aspirin may block certain enzymes that help cancer cells grow. The trial enrolled 81 adults with a history of colon polyps and measu…

This study looks at whether taking low-dose aspirin can lower the risk of colorectal cancer in people who have already had precancerous polyps removed. Researchers measure changes in certain stem cell markers in the colon and other substances in the blood and urine. The goal is t…

This large pilot study in Norway is comparing two common colorectal cancer screening methods—flexible sigmoidoscopy (a one-time scope exam) and biennial fecal immunochemical testing (a stool test)—to see which works best for the general population. Over 140,000 men and women aged…

This large study is testing whether a screening procedure called flexible sigmoidoscopy can lower the number of colorectal cancer cases and deaths. About 100,000 men and women aged 50-64 in Norway are taking part. The study also looks at adding a stool blood test and how screenin…

This study tests whether adding canned navy beans to your daily diet can improve gut bacteria and lower obesity-related cancer risk. About 71 adults who are overweight and have a history of colorectal polyps or cancer will eat beans for 8 weeks. Researchers will check changes in …

This study tests whether taking two drugs, eflornithine and sulindac, together can lower the chance of new high-risk growths or a second colon cancer in people who have already had stage 0 to III colon or rectal cancer. About 350 participants who are cancer-free after surgery wil…

This study looks at how Western habits—like drinking alcohol and eating late—might raise the risk of colorectal cancer. Twelve adults who have had colon polyps in the past will try four different weekly routines, including eating at normal times or late, with or without alcohol. …

This study looks at whether a 6-month or 12-month follow-up colonoscopy is better for people who had a large colon polyp (20-50 mm) removed that was not cancerous. About 546 adults will be assigned to one of the two follow-up schedules. The goal is to see which timing finds any r…

This study looks at whether telling people over 45 their genetic risk for colorectal cancer helps them decide to get their first colonoscopy. Researchers will track how many people schedule a colonoscopy after learning their risk, and compare findings like polyps between risk gro…

This study looks at genetic and molecular markers in tissue and stool samples from people with colon cancer, colon polyps, and healthy controls. Researchers aim to understand how these markers differ and how they relate to cancer development. The study involves 582 participants a…