Colchicine poisoning
MONDO:0017859A potentially life-threatening poisoning, due to ingestion of the drug or consumption of the plant Colchicum autumnale, that usually begins with gastrointestinal symptoms (e.g. abdominal pain, nausea, vomiting, and diarrhea, that cause severe dehydration) and an initial leukocytosis leading to marrow failure (24 hours after ingestion), followed by potentially fatal multi-organ failure with mental status change, oliguric renal failure, disseminated intravascular coagulation, electrolyte imbalance, acid-base disturbance, cardiac failure/arrest and shock within 1-3 days.
10 clinical trials for this condition and its sub-types.
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Old gout drug may keep heart in rhythm after valve surgery
Prevention CompletedThis study tested whether colchicine, an anti-inflammatory drug used for gout, can prevent new-onset atrial fibrillation and the need for a permanent pacemaker in people undergoing transcatheter aortic valve replacement (TAVI). About 120 older adults with severe aortic stenosis w…
Phase: PHASE3 • Sponsor: Insel Gruppe AG, University Hospital Bern • Aim: Prevention
Last updated Jun 27, 2026 13:01 UTC
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Can a common gout drug ease a tough type of heart failure?
Symptom relief CompletedThis study tested whether colchicine, an anti-inflammatory drug, can lower inflammation in people with a specific type of heart failure called HFpEF. 42 adults with heart failure symptoms and signs of inflammation took part. The goal was to see if colchicine could reduce markers …
Phase: PHASE1, PHASE2 • Sponsor: I.M. Sechenov First Moscow State Medical University • Aim: Symptom relief
Last updated Jun 27, 2026 12:23 UTC