Cholestasis

This study tests a special oxygen tube placed in the mouth during a procedure called ERCP, which is used to treat bile duct and pancreas problems. The goal is to see if this method can prevent low oxygen levels that often happen when patients are deeply sedated. About 410 adults …

This study tests whether giving a single intravenous dose of esketamine during a C-section can reduce the intense itching that often follows surgery in women with intrahepatic cholestasis of pregnancy. 160 women will be randomly assigned to receive either esketamine or a placebo …

This early-phase study tests whether infants with biliary atresia can tolerate oral N-Acetylcysteine (NAC) mixed into applesauce. Twelve infants will first receive plain applesauce, then NAC at increasing doses. The goal is to see if they can keep the medicine down without vomiti…

This early-stage study tests a drug called maralixibat in 28 pregnant women with intrahepatic cholestasis of pregnancy (ICP), a liver condition that causes severe itching and high bile acids. The main goal is to see if the drug is safe and tolerable for both mother and baby. Rese…

This trial looks at whether keeping or removing a drainage tube (PTCD catheter) during pancreatic surgery leads to fewer complications. About 100 patients with jaundice from tumors will be randomly assigned to one of two groups. The main goal is to see which approach reduces seri…

This study looks at 100 adults with obstructive jaundice to see if the type of anesthesia used during a procedure called ERCP affects how well it works and how safe it is. The goal is to find out which anesthesia leads to better success rates, fewer complications, and higher sati…

This study looks at 140 adults who need a plastic stent to open a blocked bile duct. If their bile has bacteria, they are randomly assigned to have the stent replaced after 1 month instead of the usual 3 months. The goal is to see if earlier replacement lowers the chance of the s…

This study will examine 106 infants under two years old who have cholestasis (a liver condition) to see how many also have congenital heart defects and how their development is affected. Researchers will use echocardiograms and developmental assessments. The goal is to better und…